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马小迪, 王婧欢, 聂宏, 孙丹, 陈着, 何瑞瑞, 董晓红.药食同源植物中的生物碱抗肿瘤的研究进展[J].湖南中医药大学学报英文版,2025,45(3):569-576.[Click to copy
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| 药食同源植物中的生物碱抗肿瘤的研究进展 |
| 马小迪,王婧欢,聂宏,孙丹,陈着,何瑞瑞,董晓红 |
| (黑龙江中医药大学佳木斯学院, 黑龙江 佳木斯 154007;黑龙江中医药大学, 黑龙江 哈尔滨 150040;陕西省中医医院, 陕西 西安 710003) |
| 摘要: |
| 生物碱是一类天然有机化合物，广泛存在于多种中草药中，其结构复杂、种类多样，含有丰富的生物活性物质，可有效抑制肿瘤生长，改善患者生存质量，可用于治疗肿瘤在内的多种慢性疾病。然而，其抗肿瘤的具体机制尚不明确。近年来，基因组学、转录组学、代谢组学等多组学研究技术和分析方法不断发展和完善，为药食同源植物中的生物碱抗肿瘤研究提供了新的认知路径，通过该技术对药食同源植物中的生物碱抗肿瘤机制进行系统归纳和分析，有利于揭示药食同源植物中的生物碱与恶性肿瘤病理进程，进而为开发针对抗肿瘤及其并发症的功能性食品提供指导，有助于推动中医药与现代医学在系统科学和生命组学领域的融合与创新，同时为抗肿瘤治疗提供思路与借鉴。基于此，阐述药食同源植物中的生物碱在抗肿瘤中的多组学联合作用机制，为恶性肿瘤的防治提供重要理论依据。 |
| 关键词: 药食同源 抗肿瘤 生物碱 多组学 文献计量 |
| DOI：10.3969/j.issn.1674-070X.2025.03.029 |
| Received:November 12, 2024 |
| 基金项目:黑龙江省教育科学规划课题项目（2024GJB1424175）；黑龙江省中医药科研课题项目（ZHY2022-134）；黑龙江中医药大学研究生创新科研项目（2024yjscx025）。 |
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| Research progress on the anti-tumor effects of alkaloids in medicinal and edible homologous plants |
| MA Xiaodi, WANG Jinghuan, NIE Hong, SUN Dan, CHEN Zhuo, HE Ruirui, DONG Xiaohong |
| (Jiamusi College, Heilongjiang University of Chinese Medicine, Jiamusi, Heilongjiang 154007, China;Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China;Shaanxi Provincial Hospital of Chinese Medicine, Xi'an, Shaanxi 710003, China) |
| Abstract: |
| Alkaloids, a class of natural organic compounds widely present in various Chinese medicinal herbs, possess complex structures, diverse types, and rich bioactive substances. They can effectively inhibit tumor growth and improve patients’ quality of life, and can be used to treat chronic diseases including tumors. However, their specific anti-tumor mechanisms remain unclear. In recent years, multi-omics research technologies and analytical methods, such as genomics, transcriptomics, and metabolomics, have continuously developed and improved, providing a new cognitive path for the anti-tumor research of alkaloids in medicinal and edible homologous plants. By systematically summarizing and analyzing the anti-tumor mechanisms of alkaloids from these plants using these technologies, it is conducive to revealing the relationship between alkaloids in medicinal and edible homologous plants and the pathological processes of malignant tumors, thereby guiding the development of functional foods targeting tumor and their complications. This approach helps promote the integration and innovation of Chinese medicine and modern medicine in the fields of systems science and life omics, and also provides ideas and references for anti-tumor treatment. Based on this, this study elucidates the multi-omics integrated mechanisms of alkaloids in medicinal and edible homologous plants in anti-tumor effects, providing theoretical support for the optimization of prevention and treatment strategies for malignant tumors. |
| Key words: medicinal and edible homology anti-tumor alkaloid multi-omics literature measurement |
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