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吴丽通, 高瑞松, 林群芳, 龙衍, 谢雨宏, 张烈, 田雪飞, 周青.基于中医时间医学探讨择时治疗在前列腺癌中的应用策略[J].湖南中医药大学学报英文版,2025,45(3):563-568.[Click to copy
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| 基于中医时间医学探讨择时治疗在前列腺癌中的应用策略 |
| 吴丽通,高瑞松,林群芳,龙衍,谢雨宏,张烈,田雪飞,周青 |
| (湖南中医药大学第一附属医院, 湖南 长沙 410007;湖南中医药大学中西医结合学院, 湖南 长沙 410208) |
| 摘要: |
| 探讨择时治疗在前列腺癌治疗中的应用，并强调中医药在此治疗策略中的综合应用。重点分析择时治疗的基础机制，包括生物钟与癌症进展的关联、作用原理以及中医药对生物钟的理解和理论渊源，并综述目前择时治疗在前列腺癌中的应用情况。进一步探讨中医药在择时治疗中减轻毒副作用、提高疗效的潜力，并讨论当前研究的限制与临床挑战。 |
| 关键词: 前列腺癌 择时治疗 昼夜节律 中医时间医学 生物钟 子午流注 |
| DOI：10.3969/j.issn.1674-070X.2025.03.028 |
| Received:November 20, 2024 |
| 基金项目:国家自然科学基金项目（82074450，82374460）；国家自然科学基金区域创新发展联合基金重点支持项目（U20A20408）；湖南中医药大学研究生创新研究项目（2023CX08）。 |
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| Application strategies of chronotherapy in prostate cancer based on Chinese chronomedicine |
| WU Litong, GAO Ruisong, LIN Qunfang, LONG Yan, XIE Yuhong, ZHANG Lie, TIAN Xuefei, ZHOU Qing |
| (The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China;School of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| This study explores the application of chronotherapy in the treatment of prostate cancer (PCa) and emphasizes the comprehensive application of Chinese medicine (CM) in this therapeutic strategy. It focuses on the fundamental mechanisms of chronotherapy, including the association between the biological clock and cancer progression, the principles of action, as well as the understanding and theoretical origins of the biological clock in CM. It also reviews the current application of chronotherapy in PCa. Furthermore, it discusses the potential of CM in chronotherapy to alleviate side effects and enhance therapeutic efficacy, and addresses the limitations and clinical challenges of current research. |
| Key words: prostate cancer chronotherapy circadian rhythm Chinese chronomedicine biological clock midnight-noon ebb-flow |
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