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陈佳文，彭清华，姚小磊，王方，李怀风，吴权龙.密蒙花总黄酮对去势雄鼠干眼症泪腺组织中白细胞介素一1表达的影响[J].湖南中医药大学学报英文版,2011,31(9):16-18.[Click to copy
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| 密蒙花总黄酮对去势雄鼠干眼症泪腺组织中白细胞介素一1表达的影响 |
| 陈佳文，彭清华，姚小磊，王方，李怀风，吴权龙 |
| (湖南中医药大学第一附属医院眼科学重点学科) |
| 摘要: |
| 〔摘要〕目的观察密蒙花总黄酮对去势导致干眼症雄鼠泪腺组织中白细胞介素一1(3 (interleukin-1(3 , IL-1团表达的
影响、方法健康1个月Wistar雄性大鼠随机分为正常组、假手术对照组、模型组、雄激素组、密蒙花总黄酮组，造模后1,
3,5个月3个不同时间段处死，观察泪腺组织中IL-1日表达的病理形态学改变，并用免疫组织化学方法检测泪腺组织中
IL-1日表达〔结果正常组、假手术对照组、丙酸辜酮组、密蒙花总黄酮组IL-1日表达显著低于模型组，差异有统计学意义
( P<0.05或P<0.01);正常组、假手术对照组的IL-1(3表达显著低于丙酸辜酮组、密蒙花总黄酮组，差异有统计学意义(P<
0.05〔结论密蒙花总黄酮通过抑制去势干眼症雄鼠泪腺组织中IL-1(3的表达，进而抑制干眼症泪腺的炎症反应〔 |
| 关键词: 干眼症 密蒙花总黄酮 白细胞介素一1队去势雄鼠 泪腺 |
| DOI： |
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| 基金项目:〔基金项目〕国家自然科学基金资助项日(30772824);教育部高等学校博卜学科点专项基金资助项日(200805410004);湖南省自然科学基金资
助项日(07JJ3049) ;湖南省科技厅科研基金资助项日(2009FJ3001);国家中医药管理局中医眼科学重点学科建设项日;湖南省中医五官科学重
点学科建设项日 |
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| Effect of inBuddlejalacrimalofficinalis flavones ongland in castrated ratsexpression of IL一1pwith dry eye |
| CHEN Jia-wen, PENG Qing-hua, YAO Xiao-Lei, WANG Fang, LI Huai-feng，
WU Quan-long |
| (、I}ey Discipline of Ophthalmology，First Affiliated Hospital, TCM University of Hunan,) |
| Abstract: |
| (Abstract〕 Objective To assess the effects of buddleja officinalis flavones on
(IL一1p)expression in the lacrimal gland of castrated rats with dry eye. Methods
one month old were randomly divided into normal group, sham group, model group,
interleukin-1p
Wistar
androgen
rats in
and therapy group with Buddl句a officinalis flavones. After model established, the
rats were
group
k;lled
at 1 month, 3 months and 5
lacrimal gland
cults Compared
、、ere
observed and
months,
IL一1p
and then.
expression
the
、、as
pathomorphology changes of IL一1 p in
detected with Immunohistochemistry. Re-
with model group, the IL-1 p expression in
other three groups were
less signicantly
(P<0.05
than that
or P<0.01); and the IL一1(3 expression
in normal and sham groups were
less significantly
in androgen and therapy groups (P<0.05). Conclusion Buddleja officinalis flavones
canthrough inhibiting expression of IL一1(3 in lacrimal gland of castrated rats[()二、Iuce inflammation
in lacrimal gland with dry eye. |
| Key words: Buddleja ofFicinalis flavones dry eye interleukin一1[3 (IL一1 [3) castrated rats lacrimal bland |
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