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韦敏、郑生智、马
红、吕
晔.枸杞多糖对人卵巢癌裸鼠IGF- I , IGFR ,
IGFBP-1水平干预作用的研究[J].湖南中医药大学学报英文版,2011,31(9):19-22.[Click to copy
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| 枸杞多糖对人卵巢癌裸鼠IGF- I , IGFR ,
IGFBP-1水平干预作用的研究 |
| 韦敏、郑生智、马
红、吕
晔 |
| ((1.中国科学院江苏省植物研究所，江苏南京210014;2南京中医药大学，江苏南京210029)) |
| 摘要: |
| [摘要〕目的研究构祀多糖对人卵巢癌裸鼠IGF-I , IGFR , IGFBP-1水平干预的作用、方法利用卵巢癌细胞SK-
OV-3腹腔种植于BABLJc雌性裸鼠建立荷人卵巢癌裸鼠腹腔种植瘤模型，观察其对人卵巢癌裸鼠的干预作用〔结果
模型组血清中IGF- I水平、卵巢组织中IGFBP-1及IGFR水平与空白组差异均有统计学意义(P<0.01)，显示造模成
功、构祀多糖能降低肿瘤引起的IGF- I水平的升高，与空白组比较无统计学意义(P>0.05 )，与模型组比较差异有统计
学意义(P<0.01);能升高由于肿瘤引起的IGFBP-1表达的卜调，与空白组比较无统计学意义(P>0.05)，与模型组比较
差异有统计学意义，高、中剂量组(P<0.01)，低剂量组(P<0.05);能降低肿瘤引起的IGFR水平的升高，与空白组比较
无统计学意义(P>0.05)，与模型组比较差异均有统计学意义(P<0.01)、结论构祀多糖能降低卵巢肿瘤引起的IGF-
I , IGFR水平的上升.IGFBP-1水平的h降.对卵巢癌具有一定的抑制作用、 |
| 关键词: 构祀多糖 BALB/}裸小鼠 胰岛素样生长因子1 胰岛素样生长因子结合蛋白1 胰岛素样生长因子受体 |
| DOI： |
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| 基金项目:国家自然科学基金资助(30973927);江苏省中科院植物所青午基金资助(200802) |
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| Study of lyceum barbarum polysaccharidesoninterventingIGF-I, IGFR and IGFBP-1 levels of Humanovarian carcinoma in nude mice |
| WEI Min', ZHENG Sheng-zhi', MA HongZ, LV Ye'* |
| ((1. Chinese Academy of Science, Jiangsu Institute of Botany, Nanjing, 210014;
2. Nanjing University of Chinese Traditional Medicine, Nanjing, 210029)) |
| Abstract: |
| (Abstract〕 Objective To study the effects of Lyceum Barbarum Polysaccharides(LBP)on IGF-
I, IGFR and IGFBP一1 level of Human ovarian carcinoma of nude mice. Methods The
nude mice models were established with SIB-OV-3 transplanted into abdominal cavity of BABL/c
female mice and intervention of the polysaccharides on the mice with ovarian carcinoma. Results
The differences of IGF一I level in serum and IGFBP一land IGFR level in ovarian tissue be-
tween model group and control group were significant (P<0.01) which showed that the modelling
were successful. the polysaccharides could increase the level of IGF -I caused by
the carcinoma compared with control group (P>0.05), with high and middle dosage group (P<0.01)
and with lower dosage group (P <0.05); it also could decrease the level of IGF -I compared
with control group (P>0.05) and with all model groups (P<0.01). Conclusion LBP can decrease the
level of IGF-I and IGFR increased by the ovarian carcinoma and increase IGFBP一1 level[()in-
hibit ovarian cancer. |
| Key words: LBP:human
ovarian carcinoma
of nude
mine
IGF- T
IGFBP-1:IGFR |
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