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甄泽森, 蔡春江, 惠莹莹.中医药调控TLR4/NF-κB/NLRP3信号通路治疗缺血性脑卒中的研究进展[J].湖南中医药大学学报英文版,2026,46(8):1745-1754.[Click to copy
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| 中医药调控TLR4/NF-κB/NLRP3信号通路治疗缺血性脑卒中的研究进展 |
| 甄泽森,蔡春江,惠莹莹 |
| (天津中医药大学研究生院, 天津 301617;河北省人民医院中医科, 河北 石家庄 050051;河北外国语学院国际医学院, 河北 石家庄 051130) |
| 摘要: |
| 缺血性脑卒中（IS）发病机制复杂，主要包括神经细胞炎症反应、神经元线粒体功能障碍、氧化应激、神经细胞兴奋性毒性等。其中，神经细胞炎症反应贯穿IS发病的全过程。Toll样受体4（TLR4）/核因子κB（NF-κB）/NLR家族吡啶结构域包含3蛋白（NLRP3）信号通路是引起神经细胞炎症反应的主要通路，中药单体及其复方可通过调控该通路减轻神经细胞炎症反应，促进神经细胞功能恢复。本文系统归纳近年来相关实验研究，总结分析中药及中药复方通过调控TLR4/NF-κB/NLRP3信号通路治疗IS的作用机制，旨在为后续相关研究提供参考。 |
| 关键词: 缺血性脑卒中|TLR4/NF-κB/NLRP3信号通路|发病机制|神经细胞炎症反应|作用机制 |
| DOI：10.3969/j.issn.1674-070X.2026.08.030 |
| Received:November 03, 2025 |
| 基金项目:河北省中医药类科学研究课题计划项目（2026040）；河北省第六批老中医专家学术经验继承工作指导老师蔡春江项目组（冀中医药函2022-75号）。 |
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| Research progress on Chinese medicines regulating the TLR4/NF-κB/NLRP3 signaling pathway in the treatment of ischemic stroke |
| ZHEN Zesen, CAI Chunjiang, HUI Yingying |
| (Graduate School of Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;Department of Traditional Chinese Medicine of Hebei General Hospital, Shijiazhuang, Hebei 050051, China;Medical School, Hebei International Studies University, Shijiazhuang, Hebei 051130, China) |
| Abstract: |
| Ischemic stroke (IS) involves intricate pathogenesis, primarily neuronal inflammatory response, neuronal mitochondrial dysfunction, oxidative stress, neuronal excitotoxicity, and so on, among which neuronal inflammatory response persists throughout the whole pathological process of IS. The Toll-like receptor 4 (TLR4)/nuclear factor-κB (NF-κB)/NLR family pyrin domain containing 3 (NLRP3) signaling pathway serves as the major pathway triggering neuronal inflammatory response. Monomers of TCM compound formulas can attenuate neuronal inflammatory response and promote neuronal functional recovery by regulating this pathway. This article systematically summarizes the relevant experimental studies in recent years, summarizes and analyzes the mechanisms of TCM monomers and compound formulas in the treatment of IS via regulating TLR4/NF-κB/NLRP3 signaling pathway, to provide references for future related research. |
| Key words: ischemic stroke|TLR4/NF-κB/NLRP3 signaling pathway|pathogenesis|neuronal inflammatory reaction|mechanisms of action |
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