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晋海兵, 王吉利, 李小玉, 赵宇, 马誉辉, 徐培源, 贺自克.中药活性成分调控成骨细胞凋亡治疗股骨头坏死的研究进展[J].湖南中医药大学学报英文版,2026,46(8):1735-1744.[Click to copy
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| 中药活性成分调控成骨细胞凋亡治疗股骨头坏死的研究进展 |
| 晋海兵,王吉利,李小玉,赵宇,马誉辉,徐培源,贺自克 |
| (河南中医药大学骨伤学院, 河南 郑州 450002;河南中医药大学第二附属医院(河南省中医院), 河南 郑州 450002) |
| 摘要: |
| 成骨细胞凋亡是股骨头坏死（ONFH）病情进展的重要环节。中药活性成分具有多成分、多靶点特性，可调控B细胞淋巴瘤-2蛋白（Bcl-2）、Bcl-2相关X蛋白（Bax）及胱天蛋白酶（Caspase）等凋亡相关通路，并激活磷脂酰肌醇3-激酶/蛋白激酶B（PI3K/Akt）信号通路及核因子E2相关因子2/血红素加氧酶-1（Nrf2/HO-1）抗氧化应激相关因子，改善成骨细胞功能，促进骨修复。本文围绕成骨细胞凋亡，归纳黄酮类、多酚类、多糖类、皂苷类、萜类及其他代表性活性成分治疗ONFH的主要机制，以期为中医药防治ONFH提供参考。 |
| 关键词: 股骨头坏死|成骨细胞|细胞凋亡|中药|活性成分|综述 |
| DOI：10.3969/j.issn.1674-070X.2026.08.029 |
| Received:January 25, 2026 |
| 基金项目:河南省自然科学基金青年项目（252300423797，252300423809）；河南省重点研发与推广专项（科技攻关）项目（242102310522，242102310539）；河南省中医药科研专项（2025LHZX3057）；河南省高等学校重点科研项目计划（25B360014）；河南省医学科技计划项目（LHGJ20240660，LHGJ20250428）；河南省卫生健康委员会国家中医药传承创新中心联合共建科研专项（2024ZXZX1196）。 |
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| Research progress on bioactive constituents of Chinese medicines in treating osteonecrosis of the femoral head through regulation of osteoblast apoptosis |
| JIN Haibing, WANG Jili, LI Xiaoyu, ZHAO Yu, MA Yuhui, XU Peiyuan, HE Zike |
| (School of Orthopedics, Henan University of Chinese Medicine, Zhengzhou, Henan 450002, China;The Second Hospital of Henan University of Chinese Medicine (Henan Province Hospital of Traditional Chinese Medicine), Zhengzhou, Henan 450002, China) |
| Abstract: |
| Osteoblast apoptosis is a key process in the progression of osteonecrosis of the femoral head (ONFH). Bioactive constituents of Chinese medicines are diverse and act on multiple molecular targets. They can regulate apoptosis-related pathways involving B-cell lymphoma-2 (Bcl-2) protein, Bcl-2-associated X (Bax) protein, and cysteine-aspartic proteases (Caspase), and activate the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway and the nuclear factor erythroid 2 (E2)-related factor 2/heme oxygenase-1 (Nrf2/HO-1) antioxidant response-related factors, thereby improving osteoblast function and promoting bone repair. Focusing on osteoblast apoptosis, this paper summarizes the major mechanisms by which representative bioactive constituents, including flavonoids, polyphenols, polysaccharides, saponins, terpenoids, and other compounds, exert therapeutic effects on ONFH, with the aim of providing a reference for the prevention and treatment of ONFH with Chinese medicine. |
| Key words: osteonecrosis of the femoral head|osteoblasts|apoptosis|Chinese medicines|bioactive constituents|review |
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