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王晓畅, 郭超凡, 陈鹏, 王有鹏, 南在元.从“虚气留滞”理论探析色素失禁症伴发癫痫的中医病机[J].湖南中医药大学学报英文版,2026,46(7):1470-1475.[Click to copy
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| 从“虚气留滞”理论探析色素失禁症伴发癫痫的中医病机 |
| 王晓畅,郭超凡,陈鹏,王有鹏,南在元 |
| (重庆医科大学附属儿童医院中医科, 重庆 400014;黑龙江中医药大学研究生院, 黑龙江 哈尔滨 150036;重庆市荣昌区中医院儿科, 重庆 402460;黑龙江中医药大学附属第二医院儿科, 黑龙江 哈尔滨 150001;首都医科大学附属北京儿童医院黑龙江医院神经内科, 黑龙江 哈尔滨 150010) |
| 摘要: |
| 色素失禁症（IP）是一种罕见的X连锁显性遗传病，以特征性皮肤损害为主要表现，常伴发中枢神经系统异常，癫痫是其常见且严重的并发症。本文基于“虚气留滞”理论，结合IP的现代医学病理机制，探讨该病的中医病机，发现其以先天元气亏虚、肾精不足、脾肾两虚为本，以痰浊、瘀血、毒邪留滞脑络为标，本虚与标实之间相互影响，形成“因虚致滞、因滞更虚”的恶性循环，致癫痫反复发作。其病机演变为：初期胎禀脆弱，髓海空虚，肾精不充，脑络失养；中期脾肾阳虚，虚气不固，阳气亏乏，清阳不升，痰浊瘀血渐次内生；终期虚气急滞，毒损脑络，痰瘀毒邪互结，闭窍动风，痫证乃作。本文旨在为中西医结合治疗IP伴发癫痫提供理论参考。 |
| 关键词: 色素失禁症|虚气留滞|癫痫|脑络|痰浊|瘀血 |
| DOI：10.3969/j.issn.1674-070X.2026.07.021 |
| Received:January 18, 2026 |
| 基金项目:黑龙江省中医药管理局省级名中医专家传承工作室建设项目；黑龙江省教科文卫体系统劳模和工匠人才创新工作室项目（黑教科文卫体工发〔2022〕14号）。 |
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| TCM pathogenesis of incontinentia pigmenti complicated with epilepsy from the theory of "qi deficiency with stagnation" |
| WANG Xiaochang, GUO Chaofan, CHEN Peng, WANG Youpeng, NAN Zaiyuan |
| (Department of Traditional Chinese Medicine, Children's Hospital of Chongqing Medical University, Chongqing 400014, China;Graduate School, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150036, China;Department of Pediatrics, Rongchang District Hospital of Traditional Chinese Medicine, Chongqing 402460, China;Department of Pediatrics, the Second Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150001, China;Department of Neurology, Heilongjiang Hospital of Beijing Children's Hospital, Capital Medical University, Harbin, Heilongjiang 150010, China) |
| Abstract: |
| Incontinentia pigmenti (IP) is a rare X-linked dominant genetic disorder characterized predominantly by characteristic skin lesions, frequently accompanied by central nervous system abnormalities, with epilepsy being a common and serious complication. Based on the theory of "qi deficiency with stagnation" and integrating the modern pathological mechanisms of IP, this paper explores the TCM pathogenesis of the disease. It reveals that the root cause lies in congenital deficiency of Yuan-primordial qi, insufficiency of kidney essence, and dual deficiency of the spleen and kidney, while the manifestations are stagnation of phlegm-turbidity, stagnant blood, and toxic pathogens lingering in the brain collaterals. The interaction between root deficiency and manifestation excess forms a vicious cycle of "deficiency giving rise to stagnation, and stagnation exacerbating deficiency," leading to recurrent epileptic seizures. The evolution of pathogenesis can be delineated as follows: in the early stage, fetal constitution is fragile, the marrow sea is empty, kidney essence is insufficient, and the brain collaterals lose nourishment; in the middle stage, spleen-kidney yang deficiency weakens the defensive qi, yang qi is depleted, clear yang fails to ascend, and phlegm-turbidity and stagnant blood gradually generate internally; in the late stage, deficient qi becomes severely stagnated, toxic pathogens damage the brain collaterals, and phlegm, stagnant blood, and toxins intertwine, blocking the orifices and stirring wind, thus provoking seizure episodes. This paper aims to provide a theoretical reference for the integrated Chinese and Western medicine treatment of IP complicated with epilepsy. |
| Key words: incontinentia pigmenti|qi deficiency with stagnation|epilepsy|brain collaterals|phlegm-turbidity|stagnant blood |
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