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鄢翘楚, 丁秀, 陈一鸣, 程业刚.中药调控NF-κB信号通路治疗膜性肾病的研究进展[J].湖南中医药大学学报英文版,2025,45(12):2442-2448.[Click to copy
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| 中药调控NF-κB信号通路治疗膜性肾病的研究进展 |
| 鄢翘楚,丁秀,陈一鸣,程业刚 |
| (湖北中医药大学, 湖北 武汉 430061;湖北省中医院, 湖北 武汉 430061) |
| 摘要: |
| 膜性肾病（MN）发病机制复杂，包括炎症反应、肾纤维化、足细胞损伤以及免疫反应等多个环节。中药在通过调控核因子-κB（NF-κB）通路治疗MN中具有独特优势且疗效显著。本研究基于NF-κB信号通路，通过分析该通路在肾纤维化、炎症反应、足细胞损伤以及免疫反应中的作用，阐明该通路促进MN发生发展的病理学本质。系统总结中药有效成分、单味中药及复方通过调控NF-κB通路改善MN的作用机制，以期为临床以NF-κB为靶点治疗MN提供理论依据。 |
| 关键词: 膜性肾病 核因子-κB信号通路 炎症反应 肾纤维化 免疫反应 足细胞损伤 |
| DOI：10.3969/j.issn.1674-070X.2025.12.029 |
| Received:August 01, 2025 |
| 基金项目:湖北省自然科学基金项目（2023AFD181）。 |
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| Research progress on the regulation of NF-κB signaling pathway by Chinese medicines in treating membranous nephropathy |
| YAN Qiaochu, DING Xiu, CHEN Yiming, CHENG Yegang |
| (Hubei University of Chinese Medicine, Wuhan, Hubei 430061, China;Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, Hubei 430061, China) |
| Abstract: |
| The pathogenesis of membranous nephropathy (MN) is complex, involving multiple processes and outcomes, such as inflammatory responses, renal fibrosis, podocyte injury, and immune reactions. Chinese medicines offer distinctive advantages and thus demonstrate significant efficacy in treating MN by regulating the nuclear factor-κB (NF-κB) pathway. Based on the NF-κB signaling pathway, this study elucidates its pathological role in promoting the occurrence and development of MN by analyzing its involvement in renal fibrosis, inflammatory responses, podocyte injury, and immune reactions. Furthermore, it systematically summarizes the mechanisms of action by which the active ingredients from Chinese medicines, single Chinese medicines, and compound formulas ameliorate MN through NF-κB pathway modulation, aiming to provide a theoretical basis for targeting NF-κB in the clinical treatment of MN. |
| Key words: membranous nephropathy nuclear factor-κB signaling pathway inflammatory response renal fibrosis immune reaction podocyte injury |
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