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邝鸣, 汤洋, 宋浩, 谭洋, 周峰, 尹周安, 裴刚.从“虚损生积”论治肝纤维化[J].湖南中医药大学学报英文版,2025,45(4):753-756.[Click to copy
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| 从“虚损生积”论治肝纤维化 |
| 邝鸣,汤洋,宋浩,谭洋,周峰,尹周安,裴刚 |
| (湖南中医药大学药学院, 湖南 长沙 410208;湖南省高等普通学校中药现代化研究重点实验室, 湖南 长沙 410208;湖南中医药大学中医学院, 湖南 长沙 410208) |
| 摘要: |
| 肝纤维化属于中医学“积聚”范畴，其多因正气亏虚，气血瘀滞，积聚于肝而发病。通过分析历代医家的经验，并结合临床观察，发现肝纤维化过程中的积聚多因人体气、血、津液等不足所致。“虚损生积”是肝纤维化发展的重要病机，现代研究基于临床和实验研究，提出正气虚损导致经脉血络瘀阻，从而引发肝脏形质损伤的发病机制。基于“虚损生积”的病机理论，将肝纤维化分为初期（肝郁脾虚）、中期（肝肾阴虚）、末期（瘀血阻络）进行论治。其中，初期以疏肝健脾为主，中期以滋补肝肾为主，末期以活血化瘀为主。 |
| 关键词: 肝纤维化 虚损生积 积聚 分期论治 正气亏虚 |
| DOI：10.3969/j.issn.1674-070X.2025.04.026 |
| Received:November 15, 2024 |
| 基金项目:国家自然科学基金项目（82174271，82474388）。 |
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| Treating liver fibrosis from the perspective of "deficiency and impairment leading to abdominal masses" |
| KUANG Ming, TANG Yang, SONG Hao, TAN Yang, ZHOU Feng, YIN Zhouan, PEI Gang |
| (School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Hunan Provincial Key Laboratory of Modern Research of TCM in Higher Education Institutions, Changsha, Hunan 410208, China;School of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Liver fibrosis falls under the category of "abdominal masses" in Chinese medicine. It is mainly caused by the deficiency of healthy qi, stagnation of qi and blood, and their accumulation in the liver. By analyzing the experience of medical practitioners throughout history and combining with clinical observations, it has been found that the abdominal masses during liver fibrosis is closely associated with the deficiency of qi, blood, body fluids, and other essential substances in the human body. "Deficiency and impairment leading to abdominal masses" is an important pathogenesis in the development of liver fibrosis. Based on clinical and experimental research, modern TCM studies have proposed that the deficiency of healthy qi leads to blood stasis obstructing in meridians and collaterals, which in turn triggers liver parenchyma damage. Based on the pathogenesis theory of "deficiency and impairment leading to abdominal masses", liver fibrosis can be divided into the early stage (liver depression and spleen deficiency), the middle stage (liver and kidney yin deficiency), and the late stage (stagnant blood obstructing the meridians) for treatment. In the early stage, the focus is on soothing the liver and strengthening the spleen; in the middle stage, the focus is on nourishing the liver and kidney; and in the late stage, the focus is on circulating blood and transforming stasis. |
| Key words: liver fibrosis deficiency and impairment leading to abdominal masses abdominal masses staged treatment deficiency of healthy qi |
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