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武迎香, 牛明了, 张龙江, 甄欢欢, 齐云菲, 陈敏迪.从“脾失散精、毒邪内生”理论与线粒体自噬介导铁死亡探讨溃疡性结肠炎病机[J].湖南中医药大学学报英文版,2025,45(4):748-752.[Click to copy
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| 从“脾失散精、毒邪内生”理论与线粒体自噬介导铁死亡探讨溃疡性结肠炎病机 |
| 武迎香,牛明了,张龙江,甄欢欢,齐云菲,陈敏迪 |
| (河南中医药大学第二临床医学院, 河南 郑州 450002;河南省中医院肛肠科, 河南 郑州 450002) |
| 摘要: |
| 中医学认为“脾失散精、毒邪内生”是久痢的病机，这与线粒体自噬介导铁死亡导致溃疡性结肠炎相类似。基于“取类比象”的中医理论，“脾失散精”为线粒体自噬导致的细胞能量不足，毒邪乃铁死亡导致的炎症反应。故本文基于“脾失散精、毒邪内生”理论，探讨中医药调控线粒体自噬介导铁死亡治疗溃疡性结肠炎的作用机制，并深入解析线粒体自噬、铁死亡、溃疡性结肠炎三者的联系，为中医药现代化研究提供可靠依据和新的治疗思路。 |
| 关键词: 溃疡性结肠炎 脾失散精 毒邪内生 线粒体自噬 铁死亡 氧化应激 |
| DOI：10.3969/j.issn.1674-070X.2025.04.025 |
| Received:September 20, 2024 |
| 基金项目:河南省中医药科学研究专项课题（2023ZY2083）。 |
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| Exploring the pathogenesis of ulcerative colitis based on the theory of "spleen deficiency leading to dysfunction of essence distribution and endogenous toxic pathogens" and mitophagy-mediated ferroptosis |
| WU Yingxiang, NIU Mingliao, ZHANG Longjiang, ZHEN Huanhuan, QI Yunfei, CHEN Mindi |
| (The Second Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou, Henan 450002, China;Anorectal Department, Henan Province Hospital of TCM, Zhengzhou, Henan 450002, China) |
| Abstract: |
| Chinese medicine posits that "spleen deficiency leading to dysfunction of essence distribution and endogenous toxic pathogens" is the pathogenesis of chronic diarrhea, which is analogous to ulcerative colitis (UC) caused by mitophagy-mediated ferroptosis. Based on the TCM theory of "analogy and imagery", "spleen deficiency leading to dysfunction of essence distribution" corresponds to cellular energy deficiency resulting from mitophagy, while "endogenous toxic pathogens" are akin to inflammatory reaction triggered by ferroptosis. Therefore, this paper aims to explore the mechanism of action of TCM in regulating mitophagy-mediated ferroptosis for the treatment of UC, based on the theory of "spleen deficiency leading to dysfunction of essence distribution and endogenous toxic pathogens". Furthermore, it has provided an in-depth analysis of the interplay among mitophagy, ferroptosis, and UC, offering a reliable basis and novel therapeutic insights for the modernization of TCM research. |
| Key words: ulcerative colitis spleen deficiency leading to dysfunction of essence distribution endogenous toxic pathogens mitophagy ferroptosis oxidative stress |
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