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蒋诗琴, 罗姣, 韦春玲, 陈杨, 刘向前.五加属植物苯丙素类成分及药理作用研究进展[J].湖南中医药大学学报英文版,2024,44(7):1335-1345.[Click to copy
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| 五加属植物苯丙素类成分及药理作用研究进展 |
| 蒋诗琴,罗姣,韦春玲,陈杨,刘向前 |
| (湖南中医药大学药学院, 湖南 长沙 410208) |
| 摘要: |
| 苯丙素类成分是自然界中一类非常重要的天然有机化合物。五加科五加属植物中富含大量的苯丙素类成分，本文对五加属植物1990年至今的相关研究进行调研，共报道了104个苯丙素类化合物，是五加属植物主要活性成分之一，主要包括简单苯丙素、香豆素和木脂素，它们具有抗炎、抗氧化、抗肿瘤、改善心脑血管系统等药理作用。但临床研究较少且研究不全面，导致其开发利用具有一定局限性。为了进一步明确五加属植物中苯丙素类化合物及其药理学活性，本文系统性地归纳了五加属植物苯丙素类化学成分及药理活性，以期为五加属植物的进一步研究提供依据。 |
| 关键词: 五加属 苯丙素 香豆素 木脂素 抗炎 抗肿瘤 |
| DOI：10.3969/j.issn.1674-070X.2024.07.029 |
| Received:March 19, 2023 |
| 基金项目:湖南省自然科学基金项目（2024JJ7357）；湖南中医药大学“十四五”重点学科——生物工程学科（校行发规字〔2023〕2 号）；湖南省研究生科研创新项目（QL20220186）。 |
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| Research progress on phenylpropanoid components and their pharmacological effects in Acanthopanax Miq. plants |
| JIANG Shiqin, LUO Jiao, WEI Chunling, CHEN Yang, LIU Xiangqian |
| (School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Phenylpropanoids are crucial natural organic compounds in nature. Acanthopanax Miq. plants (Family Araliaceae) are rich in phenylpropanoids. This paper has investigated the relevant research on Acanthopanax Miq. plants from 1990 to present, and has reported a total of 104 phenylpropanoid compounds, which are one of the main active components in Acanthopanax Miq. plants, mainly including simple phenylpropanoids, coumarins, and lignans. These compounds exhibit various activities such as anti-inflammatory, antioxidant, antitumor, and improvement of cardio-cerebrovascular system. However, due to limited and incomplete clinical studies, there are certain limitations in their development and utilization. To further clarify the phenylpropanoid compounds and their pharmacological activities in Acanthopanax Miq. plants, this paper systematically summarizes the chemical components of phenylpropanoids and their corresponding pharmacological activities in Acanthopanax Miq. plants, aiming to provide a basis for further research on Acanthopanax Miq. plants. |
| Key words: Acanthopanax Miq. phenylpropanoid coumarin lignan anti-inflammatory antitumor |
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