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吴金鸿, 欧阳林旗, 欧阳婷, 邓桂明.栀子治疗肝脏疾病作用机制研究进展[J].湖南中医药大学学报英文版,2024,44(7):1346-1350.[Click to copy
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| 栀子治疗肝脏疾病作用机制研究进展 |
| 吴金鸿,欧阳林旗,欧阳婷,邓桂明 |
| (湖南中医药大学第一附属医院, 湖南 长沙 410007;湖南中医药大学药学院, 湖南 长沙 410208) |
| 摘要: |
| 肝脏疾病是严重威胁我国人民生命健康的普遍疾病，目前其治疗仍面临缺乏特效药物和药物不良反应的困境。中医药在防治肝脏疾病方面表现出独特的优势，其中栀子及其有效成分在不同类型肝脏疾病治疗中疗效显著。现代药理学研究表明，栀子具有抗炎、抗血栓、抗病毒、抗氧化、调节血脂等作用，可减轻非酒精性脂肪性肝病、肝硬化、肝损伤、肝癌等多种疾病的症状。对栀子在多种肝脏疾病的作用机制相关的新近研究进行总结，以期为栀子在防治肝脏疾病中更深入的研究及临床应用提供参考依据。 |
| 关键词: 栀子 栀子苷 肝损伤 肝纤维化 肝癌 |
| DOI：10.3969/j.issn.1674-070X.2024.07.030 |
| Received:January 26, 2024 |
| 基金项目:湖南省中医药科研计划重点项目（No.2021016）；湖南中医药大学科研基金项目（No.2019XJJJ02）；中药粉体与创新药物省部共建国家重点实验室培育基地开放基金资助项目（21PTKF1024）；湖南省卫生健康委科研项目（D202302048806）。 |
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| Research progress on mechanism of Zhizi (Gardeniae Fructus) in treating liver diseases |
| WU Jinhong, OUYANG Linqi, OUYANG Ting, DENG Guiming |
| (The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China;School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Liver diseases are widespread and seriously threaten the life and health of the Chinese people. Currently, the treatment of liver diseases still faces challenges of lack of specific drugs as well as adverse drug reactions. However, Chinese medicine has shown unique advantages in preventing and treating liver diseases, among which Zhizi (Gardeniae Fructus) and its active ingredients have significant efficacy in treating various types of liver diseases. Modern pharmacological studies have also shown that Zhizi (Gardeniae Fructus) exhibits anti-inflammatory, anti-thrombotic, anti-viral, anti-oxidation, regulating blood lipids and other effects, which can alleviate symptoms of multiple liver diseases such as non-alcoholic fatty liver disease, liver cirrhosis, liver injury, and liver cancer. This paper summarizes the recent research on the mechanism of action of Zhizi (Gardeniae Fructus) in various liver diseases, aiming to provide a reference for further research and clinical application of Zhizi (Gardeniae Fructus) in the prevention and treatment of liver diseases. |
| Key words: Zhizi (Gardeniae Fructus) geniposide liver injury liver fibrosis liver cancer |
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