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喻朝辉,何杰,邹海燕,周宁,张杜,胡鹏,张国辉,戴姣.生发止痒膏治疗雄激素性脱发的临床研究[J].湖南中医药大学学报英文版,2024,44(3):467-472.[Click to copy
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| 生发止痒膏治疗雄激素性脱发的临床研究 |
| 喻朝辉,何杰,邹海燕,周宁,张杜,胡鹏,张国辉,戴姣 |
| (宁乡市中医医院, 湖南 宁乡 410600) |
| 摘要: |
| 目的 探讨生发止痒膏治疗雄激素性脱发（androgenic alopecia， AGA）的临床疗效及对血清白细胞介素-12（interleukin-12， IL-12）、白细胞介素-33（interleukin-33， IL-33）和干扰素-γ（interferon-γ， IFN-γ）表达的影响。方法 选取2022年8月至2023年5月于宁乡市中医医院皮肤科门诊就诊的60例AGA患者，随机分为对照组和观察组，每组30例。对照组予以外用复方酮康唑发用洗剂治疗，观察组予以外用生发止痒膏治疗，每2天使用1次，疗程共24周。拍摄标准化临床照片，记录医生主观评分及头皮油脂评分；使用毛发镜图像分析系统评估头发密度和头发直径；采用ELISA法测定血清中IL-12、IL-33和IFN-γ表达水平；检测头皮环境中马拉色菌及血常规、尿常规、肝肾功能。结果 在治疗12、24周后，观察组医生主观评分均高于对照组（P<0.05），而24周后头皮油脂评分较对照组显著下降（P<0.05）；治疗18、24周后，观察组头发直径明显大于对照组（P<0.05），但头发密度在各时间点差异均无统计学意义（P>0.05）。与对照组相比，观察组治疗后血清IL-12、IL-33和IFN-γ水平均降低（P<0.05），头皮马拉色菌阳性率降低（P<0.05）。两组患者治疗前后血常规、尿常规和肝肾功能各项指标均无明显异常。结论 生发止痒膏临床治疗AGA疗效良好，安全性高，其作用机制可能是减轻头皮炎症反应和减少马拉色菌，从而缓解脱发、促进毛发再生，值得进一步推广运用。 |
| 关键词: 生发止痒膏 雄激素性脱发 白细胞介素 干扰素-γ 马拉色菌 |
| DOI：10.3969/j.issn.1674-070X.2024.03.018 |
| Received:September 18, 2023 |
| 基金项目:湖南省中医药科研计划项目（D2022116）。 |
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| Clinical efficacy of Shengfa Zhiyang Ointment in androgenic alopecia |
| YU Zhaohui,HE Jie,ZOU Haiyan,ZHOU Ning,ZHANG Du,HU Peng,ZHANG Guohui,DAI Jiao |
| (Ningxiang Hospital of Chinese Medicine, Ningxiang, Hunan 410600, China) |
| Abstract: |
| Objective To investigate the clinical efficacy of Shengfa Zhiyang Ointment (SFZYO) in androgenic alopecia (AGA) and its effects on the expressions of serum interleukin-12 (IL-12), interleukin-33 (IL-33), and interferon-γ (IFN-γ). Methods Sixty AGA patients who attended the outpatient clinic of the dermatology department in Ningxiang Hospital of Chinese Medicine from August 2022 to May 2023 were selected and randomly divided into control group and observation group, with 30 cases in each group. The control group was treated with topical compound ketoconazole hair lotion, and the observation group with topical SFZYO. The treatment in each group was administered once every two days, for a total of 24 weeks. Standardized clinical photographs was taken, the subjective scores and the scalp oil scores were recorded; hair density and hair diameter were evaluated using the trichoscopic image analysis system; serum expression levels of IL-12, IL-33, and IFN-γ were measured by ELISA; Malassezia was detected in the scalp environment; routine examinations of blood and urine as well as liver and kidney function tests were carried out. Results After 12 and 24 weeks of treatment, the subjective scores by doctors in the observation group were higher than those in the control group (P<0.05), while the scalp oil scores by patients decreased significantly after 24 weeks compared with those of the control group (P<0.05); after 18 and 24 weeks of treatment, the hair diameter in the observation group was significantly larger than that in the control group (P<0.05), but the differences in hair density between the two groups at all time points were not statistically significant (P>0.05). Compared with the control group, serum IL-12, IL-33, and IFN-γ levels were significantly reduced in the observation group after treatment (P<0.05), and the positive rate of scalp Malassezia was lower (P<0.05). There were no obvious abnormalities in the indicators of blood routine, urine routine and liver and kidney functions before and after treatment in both groups. Conclusion SFZYO has good efficacy and high safety in the clinical treatment of AGA. Its mechanism of action may be reducing the inflammatory response of the scalp and decreasing Malassezia, so as to alleviate the alopecia and promote hair regrowth, which is worthy of further popularization and application. |
| Key words: Shengfa Zhiyang Ointment androgenic alopecia interleukin interferon-γ Malassezia |
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