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黄巧艺,马丽娜,吴素素,陈温璇,裴卉,李浩.基于“虚损瘀毒”探讨阿尔茨海默病的病机与治疗[J].湖南中医药大学学报英文版,2024,44(3):461-466.[Click to copy
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| 基于“虚损瘀毒”探讨阿尔茨海默病的病机与治疗 |
| 黄巧艺,马丽娜,吴素素,陈温璇,裴卉,李浩 |
| (北京中医药大学, 北京 100029;中国中医科学院西苑医院, 北京 100091;中国中医科学院西苑医院, 北京 100091;中国中医科学院望京医院, 北京 100102) |
| 摘要: |
| 阿尔茨海默病（Alzheimer's disease， AD）是老年期痴呆最常见的一种类型，表现为多个认知领域的进行性衰退。课题组提出虚损是AD发生发展的基础，因虚致瘀、因瘀化毒、毒损脑络是AD病情进展和恶化的关键。针对AD“虚损瘀毒”的核心病机演变特点，临床以补虚益智、活血解毒为主要治法，为中医学治疗AD提供理论基础和实践指导。 |
| 关键词: 阿尔茨海默病 病机 虚损瘀毒 中医 补虚 活血 解毒 |
| DOI：10.3969/j.issn.1674-070X.2024.03.017 |
| Received:November 04, 2023 |
| 基金项目:国家重点研发计划“中医药现代化”重点专项（2022YFC3501400）；国家自然科学基金项目（82205233）。 |
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| Pathogenesis and treatment of Alzheimer's disease based on "deficiency consumption, blood stasis, and toxins" |
| HUANG Qiaoyi,MA Li'na,WU Susu,CHEN Wenxuan,PEI Hui,LI Hao |
| (Beijing University of Chinese Medicine, Beijing 100029, China;Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China;Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China;Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China) |
| Abstract: |
| Alzheimer's disease (AD) is one of the most common types of dementia in old age, which is characterized by progressive decline in several cognitive domains. The research group proposes that deficiency consumption is the basis of the development of AD, and the key to the progression and deterioration of AD is that deficiency leads to blood stasis, which turns into toxins, and toxins damage the brain collaterals. Since "deficiency consumption, blood stasis, and toxins" is the core pathogenetic progression feature of AD, the main clinical treatment method is to tonify deficiency and enhance intelligence, circulate blood and remove toxins, which provides a theoretical basis and practical guidance for the treatment of AD in Chinese medicine. |
| Key words: Alzheimer's disease pathogenesis deficiency consumption, blood stasis, and toxins Chinese medicine tonifying deficiency circulating blood removing toxins |
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