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张恒,涂红英,熊思蕾,刘彩虹,杨蒂,韩越,王雄龙,何卿,欧阳文.药用植物异黄酮类化学成分及其药理作用的研究进展[J].湖南中医药大学学报英文版,2023,43(10):1925-1931.[Click to copy
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| 药用植物异黄酮类化学成分及其药理作用的研究进展 |
| 张恒,涂红英,熊思蕾,刘彩虹,杨蒂,韩越,王雄龙,何卿,欧阳文 |
| (湖南中医药大学药学院, 湖南 长沙 410208;湖南省普通高等学校中药现代化研究重点实验室, 湖南 长沙 410208;湖南时代阳光药业股份有限公司, 湖南 永州 410116;湖南中医药大学附属第二中西医结合医院, 湖南 浏阳 410300;浏阳市中医医院, 湖南 浏阳 410300;湖南中医药大学药学院, 湖南 长沙 410208;湖南中医药大学附属第二中西医结合医院, 湖南 浏阳 410300;浏阳市中医医院, 湖南 浏阳 410300) |
| 摘要: |
| 异黄酮类化合物的基本母核为3-苯基色原酮，具有良好的药理作用。对2013—2022年国内外报道的新异黄酮类化合物的化学结构进行综述；归纳其氢谱核磁共振及碳谱核磁共振数据的特点，对其δH-2位进行了重新归属；并对其抗肿瘤、抗氧化、抑菌等方面的药理作用进行总结，以期为异黄酮类化合物的开发应用提供理论参考。 |
| 关键词: 异黄酮 化学成分 化学位移 抗肿瘤 药理作用 |
| DOI：10.3969/j.issn.1674-070X.2023.10.028 |
| Received:February 08, 2023 |
| 基金项目:湖南省自然科学基金项目（2021JJ30500）；湖南省中医药科研计划项目（2021060）；湖南省研究生科研创新项目（CX20210709，2023CX72）；湖南省大学生创新创业训练计划项目（湘教通〔2021〕197号）；湖南省普通高等学校教学改革研究项目（HNJG-2021-0577）；湖南中医药大学学位与研究生教育教学改革研究课题（2021JG04）；湖南中医药大学中药学一流建设学科（校行科字〔2018〕3号）。 |
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| Research progress on chemical constituents and pharmacological effects of isoflavonoids in medicinal plants |
| ZHANG Heng,TU Hongying,XIONG Silei,LIU Caihong,YANG Di,HAN Yue,WANG Xionglong,HE Qing,OUYANG Wen |
| (School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Key Laboratory of Modern Research of TCM, Colleges and Universities of Hunan Province, Changsha, Hunan 410208, China;Hunan Time Sun Pharmaceutical Co. Ltd., Yongzhou, Hunan 410116, China;The Second Integrated Chinese and Western Medicine Hospital of Hunan University of Chinese Medicine, Liuyang, Hunan 410300, China;Liuyang Hospital of Chinese Medicine, Liuyang, Hunan 410300, China;School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;The Second Integrated Chinese and Western Medicine Hospital of Hunan University of Chinese Medicine, Liuyang, Hunan 410300, China;Liuyang Hospital of Chinese Medicine, Liuyang, Hunan 410300, China) |
| Abstract: |
| 3-phenylchromone is the basic nucleus of isoflavonoids, which has good pharmacological effects. This paper has reviewed the chemical structures of isoflavonoids newly reported at home and abroad from 2013 to 2022. The characteristics of its hydrogen spectrum and carbon spectrum were summarized, and the δH-2 of isoflavonoids was reassigned. In addition, the pharmacological effects of anti-tumor and anti-oxidation activities, and bacteriostasis were summarized, so as to provide theoretical reference for the development and application of isoflavonoids. |
| Key words: isoflavonoids chemical constituent chemical shift anti-tumor pharmacological effects |
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