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喻玉林,文尚,张敏轶,张璋,谢辉,郭锦材.桃红四物汤抗纤维化作用及机制的研究进展[J].湖南中医药大学学报英文版,2023,43(10):1918-1924.[Click to copy
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| 桃红四物汤抗纤维化作用及机制的研究进展 |
| 喻玉林,文尚,张敏轶,张璋,谢辉,郭锦材 |
| (湖南中医药大学, 湖南 长沙 410208;长沙市口腔医院, 湖南 长沙 410006) |
| 摘要: |
| 桃红四物汤是中医学经典名方，具有抗炎、抗氧化作用。近年来，其抗纤维化作用备受关注。桃红四物汤具有抗肝纤维化、抗肾纤维化、抗肺纤维化、抗心肌纤维化及抗口腔黏膜下纤维化作用。其抗纤维化的作用机制主要通过调控转化生长因子-β/sma和mad相关蛋白（transforming growth factor-β, TGF-β/sma-and mad-related protein, smads）信号通路、细胞外信号调节激酶（extracellular signal regulated kinase, ERK）信号通路、磷脂酰肌醇激酶/蛋白激酶B（phosphatidylinositol 3-kinases/protein kinase B, PI3K/PKB）信号通路、炎症细胞因子及相关信号通路、基质金属蛋白酶活性等途径进行干预。桃红四物汤可通过多途径、多靶点发挥抗纤维化作用，在纤维化疾病治疗中具有很好的应用前景。对其抗纤维化作用及机制进行综述，以期为临床纤维化疾病治疗提供理论支持与借鉴。 |
| 关键词: 桃红四物汤 纤维化 作用机制 信号通路 基质金属蛋白酶 |
| DOI：10.3969/j.issn.1674-070X.2023.10.027 |
| Received:April 13, 2023 |
| 基金项目:湖南省自然科学基金项目（2021JJ70062）；湖南省卫生健康委员会科研计划项目（D202313048136）；湖南省中医药科研课题（B2023048）；湖南中医药大学院校联合基金项目（2022XYLH120，2022XYLH134）。 |
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| Research progress on the anti-fibrosis effects of Taohong Siwu Decoction and its mechanism |
| YU Yulin,WEN Shang,ZHANG Minyi,ZHANG Zhang,XIE Hui,GUO Jincai |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Changsha Stomatological Hospital, Changsha, Hunan 410006, China) |
| Abstract: |
| Taohong Siwu Decoction is a classic formula in Chinese medicine, which has anti-inflammatory and antioxidant effects. In recent years, its anti-fibrosis effects have attracted much attention. To be concrete, Taohong Siwu Decoction has the effects of fighting against hepatic fibrosis, renal fibrosis, pulmonary fibrosis, myocardial fibrosis, and oral submucosal fibrosis. The anti-fibrosis mechanism of action is mainly through the regulation of transforming growth factor-β (TGF-β) and sma- and mad-related protein (smads) signaling pathways, extracellular signal regulated kinase (ERK), phosphatidylinositol 3-kinases/protein kinase B (PI3K/PKB), inflammatory cytokines and related signaling pathways, matrix metalloproteinase activity, and other pathways for intervention. To sum up, Taohong Siwu Decoction can play the anti-fibrosis role through multiple channels and multiple targets, which has good application prospects in the treatment of fibrosis disease. The anti-fibrosis effects and mechanisms have thus been reviewed in this paper, so as to provide theoretical support and reference for the treatment of clinical fibrosis disease. |
| Key words: Taohong Siwu Decoction fibrosis mechanism of action signaling pathway matrix metalloproteinase |
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