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陈思雨,朱露露,农雅萍,孙梅梅,兰蕾.隔姜灸对肝郁脾虚型功能性胃肠病大鼠胃肠动力及脏器的影响[J].湖南中医药大学学报英文版,2022,42(4):583-589.[Click to copy
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| 隔姜灸对肝郁脾虚型功能性胃肠病大鼠胃肠动力及脏器的影响 |
| 陈思雨,朱露露,农雅萍,孙梅梅,兰蕾 |
| (广西中医药大学, 广西 南宁 530001;广西中医药大学附属国际壮医医院, 广西 南宁 530201) |
| 摘要: |
| 目的 观察隔姜灸对肝郁脾虚型功能性胃肠病（functional gastrointestinal disorders, FGIDs）大鼠胃肠动力及脏器的影响，探讨隔姜灸治疗肝郁脾虚型FGIDs的作用机制。方法 将50只雄性SPF级SD大鼠随机分为正常组、模型组、隔姜灸组、百忧解组和莫沙必利组。正常组自然饲养；其余4组采用复合病因法造模3周。造模成功后，隔姜灸组捆绑束缚并行隔姜灸30 min，灌服0.9%氯化钠溶液；其余3组每日捆绑束缚30 min后，模型组灌服0.9%氯化钠溶液，百忧解组灌服百忧解溶液，莫沙必利组灌服莫沙必利溶液，均连续干预2周。每日观察各组大鼠的一般情况，隔日观察各组大鼠食量变化，每周观察各组大鼠体质量变化。在造模前后及干预后分别进行旷场实验、糖水偏嗜实验；实验结束后行系统解剖、胃残留率和小肠推进率测定、脏器系数计算。结果 造模后，与正常组比较和与造模前比较，其余各组大鼠爬格子数、站立数和修饰数明显减少（P＜0.01）。干预后与造模后比较，隔姜灸组爬格子数、站立数和修饰数均显著增加（P＜0.05或P＜0.01）；其余各组大鼠无明显变化（P＞0.05）。造模后，与正常组比较，各组造模大鼠糖水偏嗜度均明显下降（P＜0.01）；与造模前比较，各组造模大鼠糖水偏嗜度均明显下降（P＜0.01）。干预后与造模后比较，隔姜灸组、百忧解组大鼠糖水偏嗜度升高（P＜0.05或P＜0.01）；余组造模大鼠糖水偏嗜度无明显变化（P＞0.05）。干预后与正常组比较，模型组和百忧解组小肠推进率均降低、胃残留率均显著升高（P＜0.01）；与模型组比较，隔姜灸组和莫沙必利组小肠推进率均显著升高、胃残留率均显著降低（P＜0.05或P＜0.01）。结论 隔姜灸能够能使旷场实验中FGIDs大鼠爬格子数、站立数、修饰数显著增加，也能明显促进FGIDs大鼠胃的排空、小肠的推进，证实了隔姜灸既能抗抑郁又能促胃肠动力，对FGIDs有确切的疗效，值得在临床和科研中进一步推广。 |
| 关键词: 功能性胃肠病 隔姜灸 胃残留率 小肠推进率 脏器系数 大鼠 |
| DOI：10.3969/j.issn.1674－070X.2022.04.011 |
| Received:November 10, 2021 |
| 基金项目:广西自然科学基金面上项目（2018GXNSFAA050148）；广西中医药适宜技术开发与推广项目（GZSY21-42）；2017桂中医大引进博士科研启动金项目（2017BS05）；广西中医药重点学科壮医经筋推拿学(GZXK-Z-20-61)；广西中医药重点学科壮医外治学(GZXK-Z-20-62)。 |
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| Effects of ginger separated moxibustion on gastrointestinal motility and organs of rats with functional gastrointestinal disorders caused by liver depression and spleen deficiency |
| CHEN Siyu,ZHU Lulu,NONG Yaping,SUN Meimei,LAN Lei |
| (Guangxi University of Chinese Medicine, Nanning, Guangxi 530001, China;International Zhuang Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi 530201, China) |
| Abstract: |
| Objective To observe the effect of ginger separated moxibustion on gastrointestinal motility and organs in rats with functional gastrointestinal disorders (FGIDs) of liver depression and spleen deficiency type, and to explore the mechanism of ginger separated moxibustion in the treatment of FGIDs of liver depression and spleen deficiency type. Methods 50 male SPF SD rats were randomly divided into normal group, model group, ginger separated moxibustion group, prozac group and mosapride group. The normal group was naturally fed; the other four groups were modeled by compound etiology for 3 weeks. After successful modeling, the ginger separated moxibustion group was bound and treated with 0.9% sodium chloride solution for 30 min; after the other three groups were bound for 30 min every day, the model group was perfused with 0.9% sodium chloride solution, prozac group was perfused with prozac solution, and mosapride group was perfused with mosapride solution for 2 weeks. The general conditions of rats in each group were observed every day, the changes of food intake of rats in each group were observed every other day, and the changes of body weight of rats in each group were observed every week. Open field experiment and sugar water preference experiment were carried out before and after modeling and after intervention; after the experiment, systematic anatomy, determination of gastric residual rate and small intestinal propulsion rate, and calculation of organ coefficient were performed. Results After modeling, compared with the normal group and before modeling, the number of climbing lattice, standing and modification of rats in other groups decreased significantly (P<0.01). After intervention, compared with after modeling, the number of climbing lattice, standing and modification in ginger separated moxibustion group increased significantly (P<0.05 or P<0.01); there was no significant change in other groups (P>0.05). After modeling, compared with the normal group, the degree of sugar water preference in each group decreased significantly (P<0.01); compared with that before modeling, the degree of sugar water preference of rats in each group decreased significantly (P<0.01). After intervention, compared with that after modeling, the sugar water preference of rats in ginger separated moxibustion group and prozac group increased (P<0.05 or P<0.01); there was no significant change in sugar water preference in the other groups (P>0.05). After intervention, compared with the normal group, the small intestinal propulsion rate decreased and the gastric residue rate increased significantly in the model group and prozac group (P<0.01); compared with the model group, the small intestinal propulsion rate were significantly increased and gastric residue rate were significantly decreased in ginger separated moxibustion group and mosapride group (P<0.05 or P<0.01). Conclusion Ginger separated moxibustion can significantly increase the number of climbing lattice, standing and modification of FGIDs rats in the open field experiment, and can also significantly promote the emptying of stomach and the advancement of small intestine in FGIDs rats. It is confirmed that ginger separated moxibustion can not only resist depression but also promote gastrointestinal motility. It has a definite curative effect on FGIDs, which is worthy to be further popularized in clinical and scientific research." |
| Key words: functional gastrointestinal disorders ginger separation moxibustion gastric residual rate small intestinal propulsion rate organ coefficient rat |
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