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周蒙蒙,程丑夫,黎鹏程.基于数据挖掘的程丑夫治疗冠心病的遣方用药规律研究[J].湖南中医药大学学报英文版,2021,41(11):1731-1736.[Click to copy
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| 基于数据挖掘的程丑夫治疗冠心病的遣方用药规律研究 |
| 周蒙蒙,程丑夫,黎鹏程 |
| (湖南中医药大学, 湖南 长沙 410208;湖南中医药大学第一附属医院, 湖南 长沙 410007) |
| 摘要: |
| 目的 应用数据挖掘的方法分析和总结程丑夫教授治疗冠心病的遣方用药规律，促进名老中医经验的传承与推广。方法 收集整理2019年10月至2021年2月程丑夫教授治疗冠心病的门诊处方，经过筛选并按照统一标准处理后，以符合纳入标准的中药处方为基础，建立数据库。运用中医传承辅助平台软件（V2.5）进行数据挖掘，对处方中的中药进行频数分析、关联分析和聚类分析。结果 本研究共收集冠心病患者病案281例，剔除不符合纳入要求的病案62例，共纳入219名冠心病患者的有效处方224则，药物127味。其中气郁痰热、瘀阻心脉证209例，气虚痰热、瘀阻心脉证15例。使用频次位居前5的药物有柴胡、黄芩、法半夏、党参、丹参；药性以温、寒、平为主，药味以辛、苦、甘为主，药物归经主要为脾、胃、肺、肝、胆、心经。经关联规则分析得出药对关联规则24条、角药关联规则23条；经核心药物聚类分析得出10个核心组合与10个新处方。结论 程丑夫教授治疗冠心病以调气化痰、活血化瘀为核心，痰瘀同治、气血并调、标本兼顾，常用小柴胡汤、小陷胸汤、丹参饮加减治疗冠心病。 |
| 关键词: 冠心病 程丑夫 数据挖掘 用药规律 柴胡 小柴胡汤 小陷胸汤 丹参饮 |
| DOI：10.3969/j.issn.1674-070X.2021.11.014 |
| Received:April 08, 2021 |
| 基金项目:国家中医药管理局“程丑夫名老中医药专家传承工作室建设”项目（国中医药人教函[2013]47号）；湖南省中医药科研计划重点课题项目（201208）。 |
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| Research on Professor Cheng Choufu's Prescription and Medication Principle in the Treatment of Coronary Heart Disease Based on Data Mining |
| ZHOU Mengemeng,CHENG Choufu,LI Pengcheng |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China) |
| Abstract: |
| Objective Using data mining method to analyze and summarize professor Cheng Choufu's medication rules in the treatment of coronary heart disease, and to promote the inheritance and promotion of famous old Chinese medicine doctor's experience. Methods The outpatient prescriptions of professor Cheng Choufu for the treatment of coronary heart disease from October, 2019 to February, 2021 were collected and sorted out, after screening and processing according to uniform standards, a database was established based on the prescriptions of traditional Chinese medicine (TCM) that met the inclusion criteria. TCM inheritance auxiliary platform software (V2.5) was used for data mining, and conducted frequency analysis, association analysis and cluster analysis of TCM in prescriptions. Results A total of 281 cases of coronary heart disease patients were collected in this study, and 62 cases that did not meet the inclusion requirements were excluded. A total of 224 prescriptions and 127 drugs of 219 patients with coronary heart disease were included in the study, including 209 cases of Qi stagnation and phlegm heat, and blood stasis blocking heart arteries syndrome, 15 cases of Qi deficiency and phlegm heat, and blood stasis blocking heart arteries syndrome. The top 5 drugs used frequently were Chaihu (Bupleuri Radix), Huangqin (Scutellariae Radix), Fabanxia (Pinelliae Rhizoma Praeparatum), Dangshen (Codonopsis Radix), Danshen (Salviae Miltiorrhizae Radix Et Rhizoma); the main properties were warm, cold and calm, with pungent, bitter and sweet as the main medicinal flavors, and the main meridian was the spleen, stomach and lungs, liver, gallbladder and heart. According to the analysis of association rules, 24 association rules of drug pair and 23 association rules of horn drugs were obtained, and 10 core combinations and 10 new prescriptions were obtained by cluster analysis of core drugs. Conclusion Professor Cheng Choufu treats coronary heart disease with regulating Qi and resolving phlegm, promoting blood circulation and resolving blood stasis as the core, treating phlegm and blood stasis at the same time, regulating both Qi and blood, and taking into consideration the treetop and root. He often uses modified Xiaochaihu Decoction, Xiaoxianxiong Decoction and Danshen Decoction to treat coronary heart disease. |
| Key words: coronary heart disease Cheng Choufu data mining medication principle Chaihu (Bupleuri Radix) Xiaochaihu Decoction Xiaoxianxiong Decoction Danshen Decoction |
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