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赵达,曹晖,胡志希.基于关联规则和聚类分析研究全国名中医治疗冠心病用药规律[J].湖南中医药大学学报英文版,2021,41(11):1726-1730.[Click to copy
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| 基于关联规则和聚类分析研究全国名中医治疗冠心病用药规律 |
| 赵达,曹晖,胡志希 |
| (湖南中医药大学中医学院, 湖南 长沙 410208;湖南中医药大学第一附属医院, 湖南 长沙 410007) |
| 摘要: |
| 目的 通过古今医案云平台（V2.2.1）探讨首批全国名中医治疗冠心病的用药规律。方法 以中国知网、万方数据库、中国生物医学数据库上已公开发表的文献为基础，收集1984年1月1日至2020年11月1日全国名中医治疗冠心病的医案，建立文献数据库，运用频数统计、聚类分析和关联规则分析等数据挖掘方法分析中药用药规律。结果 筛选出的132首处方中，共涉及中药203味，用药频数1 468次，其中使用频数≥40次的中药有10味，分别为丹参、瓜蒌、川芎、茯苓、半夏、桂枝、党参、当归、黄芪。药物四气以温、平为主，五味以甘、辛、苦为主，药物主要归属于肺、脾、心经，药物功效以活血化瘀、燥湿化痰为主。同时挖掘出12对药对组合和3个聚类方。结论 全国名中医治疗冠心病以活血化瘀、燥湿化痰治其标，补益心气、滋阴养血治其本，心气阴亏虚，痰瘀互结于心脉为胸痹的主要病机。3首聚类方中的基本组成为瓜蒌薤白半夏汤、四物汤、炙甘草汤的体现，可为临床治疗冠心病提供参考。 |
| 关键词: 冠心病 用药规律 古今医案云平台 聚类分析 关联规则 全国名中医 |
| DOI：10.3969/j.issn.1674-070X.2021.11.013 |
| Received:December 21, 2020 |
| 基金项目:国家自然科学基金项目（81774208）；广东省重点领域研发项目（2020B1111100001）。 |
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| Medication Rules of National Famous Traditional Chinese Medicine Doctors for the Treatment of Coronary Heart Disease Based on Association Rules and Cluster Analysis |
| ZHAO Da,CAO Hui,HU Zhixi |
| (Department of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China) |
| Abstract: |
| Objective To explore the medication rules of the first batch of national famous traditional Chinese medicine doctors in the treatment of coronary heart disease through the ancient and modern medical records cloud platform (V2.2.1). Methods Based on the publicly published documents on CNKI, Wanfang Database, and China Biomedical Database, the medical records of famous traditional Chinese medicine doctors in the country for the treatment of coronary heart disease from January 1, 1984 to November, 1, 2020 were collected, and the literature database were established. Frequency statistics, cluster analysis and association rule analysis were used to analyze the law of traditional Chinese medicine. Results Among the 132 prescriptions screened out, 203 Chinese medicines were involved, and the frequency of use was 1 468 times. Among them, there were 10 Chinese medicines with a frequency ≥ 40 times, which were Danshen (Salviae Miltiorrhizae Radix Et Rhizoma), Gualou (Trichosanthis Fructus), Chuanxiong (Chuanxiong Rhizoma), Fuling (Poria), Banxia (Pinelliae Rhizoma), Guizhi (Cinnamomi Ramulus), Dangshen (Codonopsis Radix), Danggui (Angelicae Sinensis Radix), Huangqi (Astragali Radix). The four Qi of the medicine were mainly warm and flat, and the five flavors were mainly sweet, pungent and bitter. The medicine was mainly attributed to the lung, spleen and heart meridian. The efficacy of the medicine was mainly to promote blood circulation to remove blood stasis, dry dampness and resolve phlegm. At the same time, 12 drug-pair combinations and 3 clustering formulas were excavated. Conclusion The national famous traditional Chinese medicine doctors treat coronary heart disease by promoting blood circulation to remove blood stasis, drying dampness and removing phlegm to treat its symptoms, replenishing heart Qi, nourishing Yin and nourishing blood to cure its root. Deficiency of heart Qi and Yin, mutual accumulation of phlegm and blood stasis in the heart pulse is the main pathogenesis of chest obstruction. The basic components of the three cluster prescriptions are the embodiment of Gualou Xiebai Banxia Decoction, Siwu Decoction and Zhigancao Decoction, which can provide references for clinical treatment of coronary heart disease. |
| Key words: coronary heart disease medication rule ancient and modern medical records cloud platform cluster analysis association rules national famous traditonal Chinese medicine doctors |
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