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李亮,韩斐.韩斐教授治疗儿童抽动障碍的用药规律研究[J].湖南中医药大学学报英文版,2020,40(8):1033-1038.[Click to copy
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| 韩斐教授治疗儿童抽动障碍的用药规律研究 |
| 李亮,韩斐 |
| (中国中医科学院广安门医院, 北京 100053) |
| 摘要: |
| 目的 分析韩斐教授治疗抽动障碍（tic disorder,TD）的用药特点，探讨其用药规律。方法 收集2018年9月1日至2019年8月31日就诊于中国中医科学院广安门医院儿科门诊，经韩斐教授诊治的TD患儿的病案数据。运用SPSS 22.0统计软件，采用频数分析、因子分析、聚类分析等统计方法进行数据挖掘。结果 本研究共纳入病例308例，剔除联合应用西药者8例，最终纳入首诊处方300首，涉及药物112味，共计6 898次。高频药物前10位是龙骨（99.67%）、酸枣仁（99.67%）、僵蚕（98.33%）、白芷（97.00%）、柴胡（96.67%）、辛夷（95.00%）、柏子仁（89.33%）、首乌藤（77.33%）、藿香（73.33%）、荆芥（67.33%）。所用药物主要为安神药、解表药、平肝息风药，药性以平、温，辛、苦（微苦）为主，主要归心、肝、肺经。因子分析得到10个公因子，聚类分析得到7个核心药物组合。结论 韩斐教授治疗TD以安神、息风、宣肺为治疗原则，尤重安神之法，并根据辨证配合使用清热药、补虚药等。 |
| 关键词: 儿童抽动障碍 用药规律 数据挖掘 安神 息风 宣肺 韩斐 名医经验 |
| DOI：10.3969/j.issn.1674-070X.2020.08.023 |
| Received:June 24, 2020 |
| 基金项目:中央级公益性科研院所基本科研业务费项目（ZZ13-024-5）。 |
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| Study on Medication Rules of Professor HAN Fei in Treating Children with Tic Disorder |
| LI Liang,HAN Fei |
| (Guang'anmen Hospital of China Academy of Chinese Medical Science, Beijing 100053, China) |
| Abstract: |
| Objective To analyze the medication characteristics of professor HAN Fei in the treatment of tic disorder (TD), and to explore his medication rule. Methods The medical record data of patients with TD treated by professor HAN Fei in the pediatric outpatient department of Guang'anmen Hospital of China Academy of Chinese Medical Science from September 1st, 2018 to August 31st, 2019 were collected. SPSS 22.0 statistical software was used, and data mining was carried out by using statistical methods such as frequency analysis, factor analysis and cluster analysis. Results A total of 308 cases were included into this study. Finally, 300 cases of first prescription were included after excluding 8 cases of combined application with western medicine, involving 112 kinds of Chinese materia medica and the total medication frequency was 6898. The first 10 high-frequency Chinese materia medica were Os Draconis (99.67%), Semen Ziziphi Spinosae (99.67%), Bombyx Batryticatus (98.33%), Radix Angelicae Dahuricae (97.00%), Radix Bupleuri (96.67%), Flos Magnoliae (95.00%), Semen Platycladi (89.33%), Caulis Polygoni Multiflori (77.33%), Herba Pogostemonis (73.33%), Herba Schizonepetae (67.33%). The medicine used were mainly for tranquillizing mind, relieving exterior syndromes and suppressing hyperactive liver for calming endogenous wind. The medicine properties were mainly to be flat, warm, pungent and bitter (slightly bitter), and they were mainly for heart, liver and lung meridian tropism. 10 common factors were obtained from factor analysis, and cluster analysis found 7 core medicine group. Conclusion The therapeutic principle of Prof. HAN in treating TD is tranquillizing mind, calming endogenous wind and facilitating lung therapy, especially pay attention to tranquillization method. Meanwhile, heat-clearing medicine and deficiency-tonifying medicine etc. were used according to syndrome differentiation. |
| Key words: children with tic disorder medication rules data mining tranquillizing mind calming endogenous wind ventilating lung HAN Fei experience of famous doctors |
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