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张薇薇.中药熏洗治疗化疗致周围神经毒性病变的临床研究[J].湖南中医药大学学报英文版,2019,39(12):1517-1520.[Click to copy
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| 中药熏洗治疗化疗致周围神经毒性病变的临床研究 |
| 张薇薇 |
| (湖南省人民医院/湖南师范大学附属第一医院中医科, 湖南 长沙 410005) |
| 摘要: |
| 目的 探讨中药熏洗治疗对恶性肿瘤化疗后患者周围神经毒性和血清神经生长因子（nerve growth factor，NGF）水平的影响。方法 选取45例恶性肿瘤化疗致周围神经病变的患者，随机分为对照组和治疗组，对照组22例给予安慰剂熏洗，治疗组给予中药熏洗，每晚1次，1周为1个疗程，共治疗4个疗程。观察两组患者临床疗效、周围神经毒性分级及血清NGF水平变化。结果 对照组总有效率36.4%，治疗组总有效率82.6%，两组总有效率差异有统计学意义（P<0.05）；两组治疗后血清NGF水平较治疗前降低（P<0.05），其中治疗组血清NGF水平明显高于对照组（P<0.05）。结论 中药熏洗治疗能改善化疗致周围神经病变临床症状并减缓血清NGF下降趋势，提高患者生活质量，是治疗化疗致周围神经毒性病变的一种可行方法。 |
| 关键词: 周围神经病变 化疗 中药熏洗 神经生长因子 |
| DOI：10.3969/j.issn.1674-070X.2019.12.021 |
| Received:September 19, 2019 |
| 基金项目:湖南省人民医院新技术、新项目（NT20184010）。 |
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| Clinical Study on the Treatment of Fumigation and Washing with Chinese Herbal Medicine for Peripheral Neurotoxicity Induced by Chemotherapy |
| ZHANG Weiwei |
| (Department of Traditional Chinese Medicine, Hunan Provincial People's Hospital, First Affiliated Hospital of Hunan Normal University, Changsha, Hunan 410005, China) |
| Abstract: |
| Objective To observe the therapeutic effects of Chinese herbal medicine fumigation and washing on peripheral neurotoxicity and serum nerve growth factor (NGF) level in patients with malignant tumor after chemotherapy. Methods A total of 45 patients with malignant tumors were randomly divided into a control group and a treatment group. The control group with 22 patients were fumigated and washed with placebo, and the treatment group was fumigated and washed with Chinese herbal medicine bag, once every evening, and 1 week as a treatment course, for totally 4 courses. The clinical efficacy, peripheral neurotoxicity grade, and changes of serum nerve growth factor (NGF) index of the 2 groups were observed. Results The total effective rate of the control group was 36.4%, 82.6% in the treatment group. There was a statistically significant difference in the total effective rate between the 2groups (P<0.05). The serum NGF levels of the 2 groups were decreased than before treatment (P<0.05), and the serum NGF level in the treatment group was significantly higher than the control group (P<0.05). Conclusion Fumigation and washing with Chinese herbal medicine can relieve the clinical symptoms of peripheral neuropathy caused by chemotherapy and reduce serum NGF levels, improve the quality of life of patients. Chinese herbal medicine fumigation and washing is a feasible method for treating peripheral neurotoxicity after chemotherapy. |
| Key words: chemotherapy peripheral neuropathy fumigation and washing with Chinese herbal medicine nerve growth factor |
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