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王东波,郭忠聪.抗癌防移片联合化疗治疗中晚期胃癌肝转移临床观察[J].湖南中医药大学学报英文版,2019,39(8):1008-1010.[Click to copy
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| 抗癌防移片联合化疗治疗中晚期胃癌肝转移临床观察 |
| 王东波,郭忠聪 |
| (长沙市妇幼保健院, 湖南 长沙 410007;湖南中医药大学第一附属医院, 湖南 长沙 410007) |
| 摘要: |
| 目的 观察抗癌防移片联合化疗对中晚期胃癌肝转移的临床疗效。方法 将60例本病患者随机分为治疗组和对照组，各30例。对照组予以SOX方案化疗，治疗组在同对照组治疗基础上加用抗癌防移片。对两组近期客观疗效、卡氏功能状态（Karnofsky Performance Status， KPS）评分、癌胚抗原（Carcino-embryonic antigen， CEA）变化及不良反应发生率进行比较。结果 治疗组近期疗效及CEA水平、KPS评分改善明显优于对照组（P<0.05），不良反应发生率明显低于对照组（P<0.05）；两组肝肾损伤均为轻度（P>0.05）。结论 抗癌防移片联合化疗可提高中晚期胃癌肝转移患者局部控制率，有效减少化疗不良反应的发生，改善患者生活质量，具有增效减毒抗癌的作用。 |
| 关键词: 中晚期胃癌 肝转移 抗癌防移片 KPS评分 |
| DOI：10.3969/j.issn.1674-070X.2019.08.017 |
| Received:May 08, 2019 |
| 基金项目:湖南省教育厅一般项目（17C1235）。 |
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| Clinical Observation on Anti-Cancer and Anti-Migration Tablets Combined with Chemotherapy in the Treatment of Liver Metastases of Advanced Gastric Cancer |
| WANG Dongbo,GUO Zhongcong |
| (Changsha Hospital for Maternal & Child Health Care, Changsha, Hunan 410007, China;The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China) |
| Abstract: |
| Objective To observe the clinical therapeutic effects of anti-cancer and anti-migration tablets on liver metastasis of advanced gastric cancer. Methods A total of 60 patients were randomly divided into a treatment group and a control group, with 30 cases in each group. The control group was treated with chemotherapy of SOX plan, and the treatment group was supplemented with anti-cancer and anti-migration tablets on the same premise as the control group. The short-term objective efficacy, KPS score, CEA level changes and incidence of adverse reactions of the 2 groups were compared. Results The short-term efficacy, CEA level and KPS score of the treatment group were significantly better than the control group (P<0.05), and the incidence of adverse reactions was significantly lower than that of the control group (P<0.05). The liver and kidney damage of both groups were mild (P> 0.05). Conclusion Anti-cancer and anti-migration tablets combined with chemotherapy can improve the local control rate of patients with advanced gastric cancer liver metastasis, effectively reduce the occurrence of adverse reactions of chemotherapy, improve the quality of life of patients, and have the effect of increasing effect, reducing toxicity and anti-cancer. |
| Key words: advanced gastric cancer liver metastasis anticancer and anti-migration tablets KPS score |
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