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张序晴,彭兰,李赛,李耀伟,喻阳,曾嵘,任卫琼,邓凯文,王志琪.附子-甘草对离体蛙心的影响及其指纹图谱研究[J].湖南中医药大学学报英文版,2019,39(2):184-189.[Click to copy
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| 附子-甘草对离体蛙心的影响及其指纹图谱研究 |
| 张序晴,彭兰,李赛,李耀伟,喻阳,曾嵘,任卫琼,邓凯文,王志琪 |
| (湖南中医药大学研究生院, 湖南 长沙 410208;湖南中医药大学湘杏学院, 湖南 长沙 410208;湖南中医药大学药学院, 湖南 长沙 410208;湖南中医药大学附属第一医院, 湖南 长沙 410000;湖南中医药大学药学院, 湖南 长沙 410208;湖南省中药饮片标准化及功能工程技术中心, 湖南 长沙 410208) |
| 摘要: |
| 目的 研究附子-甘草合煎液和混合液对离体蛙心的影响及其物质基础。方法 通过离体蛙心实验观察附子-甘草合煎液和混合液对离体正常蛙心和心衰蛙心功能的影响，应用高效液相色谱法建立并测定附子-甘草煎液的HPLC指纹图谱。结果 附子-甘草合煎液与混合液的强心作用有差别；附子与甘草配伍后其指标成分的含量发生了明显变化，且合煎液与混合液的成分变化差别显著。结论 附子-甘草合煎液和混合液对离体蛙心的作用及其指纹图谱均不一致。 |
| 关键词: 附子 甘草 离体蛙心 指纹图谱 合煎液 混合液 |
| DOI：10.3969/j.issn.1674-070X.2019.02.008 |
| Received:September 13, 2018 |
| 基金项目:国家自然科学基金项目（81503492，81473617）；湖南省自然科学基金项目（2015JJ6079）；湖南省教育厅教改项目（湘教通〔2016〕400-321）；湖南中医药大学教改项目（2018-JG021） |
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| Effect of Aconite-Licorice on the Isolated Frog Heart and Its Fingerprint |
| ZHANG Xuqing,PENG Lan,LI Sai,LI Yaowei,YU Yang,ZENG Rong,REN Weiqiong,DENG Kaiwen,WANG Zhiqi |
| (Graduate School, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Xiangxing College, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410000, China;School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Hunan Provincial Traditional Chinese Medicine Decoction Pieces Standardization and Functional Engineering Technology Center, Changsha, Hunan 410208, China) |
| Abstract: |
| Objective To explore the effects of aconite-licorice combined decoction and aconite-licorice mixed liquid on the isolated frog heart and their material basis. Methods The effects of aconite-licorice combined decoction and aconite-licorice mixed liquid on the isolated normal and failing frog hearts were evaluated by isolated frog heart experiment. Their HPLC fingerprints were established and compared. Results There was a difference in the cardiotonic effect between aconite-licorice combined decoction and aconite-licorice mixed liquid. The content of index components changed significantly after the combination of aconite and licorice, and there was a significant difference in component changes between the combined decoction and the mixed liquid. Conclusion Aconite-licorice combined decoction and aconite-licorice mixed liquid have different effects on the isolated frog heart as well as different fingerprints. |
| Key words: aconite licorice isolated frog heart fingerprint decoction mixture |
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