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黎志清,何清湖,宾东华,周青,周兴,李玲,李波男.知柏地黄丸治疗肾阴亏损型精液不液化的临床观察[J].湖南中医药大学学报英文版,2019,39(1):73-76.[Click to copy
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| 知柏地黄丸治疗肾阴亏损型精液不液化的临床观察 |
| 黎志清,何清湖,宾东华,周青,周兴,李玲,李波男 |
| (湖南中医药大学中西医结合学院, 湖南 长沙 410208;湖南中医药大学第一附属医院, 湖南 长沙 410007) |
| 摘要: |
| 目的 观察知柏地黄丸治疗精液不液化的临床疗效。方法 采用随机、对照的研究方法，将60例精液不液化的男性患者随机分为治疗组和对照组，各30例，对照组口服维生素E软胶囊，0.1 g/次，3次/d，葡萄糖酸锌片，0.105 g/次，2次/d，治疗组口服知柏地黄丸，1次8丸，3次/d，两组各治疗60 d。比较两组治疗前后的中医证候评分、精液分析及精液液化情况。结果 治疗组治疗后的前向运动精子率、精子畸形率、精浆锌及精浆果糖水平较治疗前差异有统计学意义（P<0.05）；两组治疗后精液液化情况均有所改善，两组比较差异有统计学意义（P<0.05），治疗组在缩短精液液化时间方面优于对照组；两组治疗后临床症状均有所改善，对照组有效率42.86%，治疗组有效率82.76%，两组比较差异有统计学意义（P<0.05），治疗组在改善临床症状方面优于对照组。结论 知柏地黄丸治疗精液不液化疗效确切，值得临床推广应用。 |
| 关键词: 精液不液化 知柏地黄丸 肾阴亏损 知母 黄柏 |
| DOI：10.3969/j.issn.1674-070X.2019.01.017 |
| Received:November 07, 2018 |
| 基金项目:国家自然科学基金资助项目（81774324、81603634）。 |
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| Clinical Efficacy of Zhibai Dihuang Pill in Treatment of Semen Non-liquefaction with Kidney Yin Deficiency |
| LI Zhiqing,HE Qinghu,BIN Donghua,ZHOU Qing,ZHOU Xing,LI Ling,LI Bonan |
| (School of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China) |
| Abstract: |
| Objective To evaluate the clinical efficacy of Zhibai Dihuang Pill in the treatment of semen non-liquefaction.Methods In a randomized controlled clinical trial, 60 male patients with semen non-liquefaction were randomly and equally divided into treatment group and control group. The control group received oral administration of vitamin E soft capsules 0.1 g each time, 3 times daily and zinc gluconate pills 0.105 g each time, 2 times daily. The treatment group received oral administration of Zhibai Dihuang Pill 8 pills each time, 3 times daily. Both groups were treated for 60 days. The scores for traditional Chinese medicine syndrome, semen analysis results, and semen liquefaction were evaluated in the two groups before and after treatment.Results After treatment, the treatment group had significantly improved percentage of forward motile sperm, rate of sperm deformation, and levels of zinc and fructose in seminal plasma (all P<0.05). Both groups showed a significant improvement in semen liquefaction after treatment, and there was a significant difference in semen liquefaction between the two groups (P<0.05). The treatment group was superior to the control group in shortening semen liquefaction time. Both groups had improved clinical symptoms after treatment; the treatment group had a significantly higher response rate than the control group (82.76% vs 42.86%, P<0.05), suggesting that the treatment group was superior to the control group in improving clinical symptoms.Conclusion Zhibai Dihuang Pill is effective in the treatment of semen non-liquefaction, which holds promise for clinical application. |
| Key words: semen non-liquefaction Zhibai Dihuang Pill kidney Yin deficiency Rhizoma Anemarrhenae Phellodendri Chinensis Cortex |
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