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张展,杨凯,姜德龙,张兰.应用改良Homa公式评价益气养阴法联合短期胰岛素泵强化的初诊2型糖尿病气阴两虚型患者的胰岛功能[J].湖南中医药大学学报英文版,2019,39(1):77-80.[Click to copy
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| 应用改良Homa公式评价益气养阴法联合短期胰岛素泵强化的初诊2型糖尿病气阴两虚型患者的胰岛功能 |
| 张展,杨凯,姜德龙,张兰 |
| (辽宁中医药大学, 辽宁 沈阳 110032;辽宁中医药大学附属医院, 辽宁 沈阳 110032;沈阳市浑南区医院, 辽宁 沈阳 110000) |
| 摘要: |
| 目的 应用改良Homa公式评价益气养阴法联合短期胰岛素泵强化的初诊2型糖尿病（type 2 diabetes mellitus，T2DM）气阴两虚型患者的胰岛功能。方法 将40例初诊气阴两虚型T2DM患者随机分成对照组和治疗组，每组20例。对照组单纯予以西医胰岛素泵强化治疗，治疗组在对照组的基础上结合益气养阴法治疗，两组的治疗周期均为2周。观察两组治疗前后空腹血糖及空腹C肽水平变化，并应用改良Homa公式计算及评价其胰岛功能。结果 组内及组间治疗前后胰岛素抵抗指数在应用改良Homa公式计算后得出的Homa-IR与胰岛功能Homa-islet值均有明显改善（P<0.05），且治疗组Homa-IR与Homa-islet改善情况明显优于对照组（P<0.05）；而C肽无显著性差异（P>0.05）。治疗前后两组中医证候疗效积分比较，部分症状的中医证候积分比较具有统计学差异（P<0.05）。结论 益气养阴法联合短期胰岛素泵强化对初诊T2DM胰岛功能的改善效果及中医证候疗效方面更显著，且改良Homa公式对胰岛功能的评价较单纯C肽评价更优，能够较为准确、完善的反应出患者胰岛功能。 |
| 关键词: 2型糖尿病 气阴两虚 改良Homa公式 C肽 胰岛功能 中医证候 |
| DOI：10.3969/j.issn.1674-070X.2019.01.018 |
| Received:April 14, 2018 |
| 基金项目:辽宁省自然科学基金指导计划项目（201602505）；沈阳市科学技术计划项目（F16-205-1-27）。 |
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| Evaluation of Effect of Qi-Tonifying and Yin-Nourishing Regimen Combined with Short-Term Intensive Insulin Pump Therapy on Islet Function of Patients with an Initial Diagnosis of Type 2 Diabetes Mellitus and Deficiency of Both Qi and Yin Using the Modified HOMA Formula |
| ZHANG Zhan,YANG Kai,JIANG Delong,ZHANG Lan |
| (Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning 110032, China;The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning 110032, China;Shenyang Hunnan District Hospital, Shenyang, Liaoning 110000, China) |
| Abstract: |
| Objective To evaluate the effect of Qi-tonifying and Yin-nourishing regimen combined with short-term intensive insulin pump therapy on the islet function of patients with an initial diagnosis of type 2 diabetes mellitus (T2DM) and deficiency of both Qi and Yin using the modified HOMA formula.Methods A total of 40 patients with an initial diagnosis of T2DM and deficiency of both Qi and Yin were randomly divided into control group and treatment group, with 20 cases in each group. The control group was given intensive insulin pump therapy alone, and the treatment group was given Qi-tonifying and Yin-nourishing regimen combined with the treatment for the control group. The treatment cycle for both groups was 2 weeks. The changes in the levels of fasting blood glucose and fasting C-peptide after treatment were evaluated in the two groups, and the islet function was calculated and evaluated using the modified HOMA formula.Results Significant improvements were observed after treatment both within and between the two groups in the insulin resistance indices measured by the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) and HOMA-islet calculated with the modified HOMA formula (P<0.05); the improvements in HOMA-IR and HOMA-islet were significantly greater in the treatment group than in the control group (P<0.05); but there was no significant difference in C-peptide (P>0.05). There were significant differences in the outcome scores for certain traditional Chinese medicine (TCM) syndromes after treatment between the two groups (P<0.05).Conclusion Compared with intensive insulin pump therapy alone, Qi-tonifying and Yin-nourishing regimen combined with short-term intensive insulin pump therapy shows a greater effect in improving the islet function and outcome for TCM syndromes in patients with an initial diagnosis of T2DM and deficiency of both Qi and Yin. The modified HOMA formula is superior to C-peptide alone in the evaluation of islet function; therefore, it can more accurately and comprehensively reflect the islet function of patients. |
| Key words: type 2 diabetes mellitus deficiency of both Qi and Yin modified HOMA formula C-peptide islet function traditional Chinese medicine syndrome |
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