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陈宝艳,李坤寅,甄玉花.疏肝健脾法对产后缺乳肝郁脾虚证大鼠泌乳干预作用的实验研究[J].湖南中医药大学学报英文版,2018,38(12):1374-1379.[Click to copy
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| 疏肝健脾法对产后缺乳肝郁脾虚证大鼠泌乳干预作用的实验研究 |
| 陈宝艳,李坤寅,甄玉花 |
| (广州中医药大学第一附属医院, 广东 广州 510405;广州中医药大学第三附属医院, 广东 广州 510378) |
| 摘要: |
| 目的 探讨疏肝健脾法对产后缺乳肝郁脾虚证大鼠泌乳的干预作用。方法 采用甲磺酸溴隐亭溶液+慢性束缚法复制大鼠产后缺乳肝郁脾虚病证结合动物模型，将60只Wistar大鼠随机分为空白对照组，模型组，西药对照组，中药低、中、高剂量组，每组10只，通过大鼠宏观表征、体质量、每小时泌乳量、仔鼠窝净增重、旷场实验、D-木糖排泄率观察疏肝健脾法的干预作用。结果 与模型组相比，西药对照组和中药低、中、高剂量组均可改善缺乳大鼠的宏观表征、增加大鼠体质量和仔鼠净增重，增加大鼠每小时泌乳量，增加大鼠水平运动和垂直运动次数，增加大鼠尿D-木糖排泄率（P<0.05），且中药中剂量组效果最好。结论 疏肝健脾法能促进肝郁脾虚证产后缺乳大鼠泌乳，同时可改善大鼠宏观表征、行为学表现及脾胃功能。 |
| 关键词: 疏肝健脾法 产后缺乳 肝郁脾虚证 动物模型 泌乳量 |
| DOI：10.3969/j.issn.1674-070X.2018.12.005 |
| Received:September 06, 2018 |
| 基金项目:国家自然科学基金项目（81603653）。 |
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| Effect of Liver-Soothing and Spleen-Strengthening Prescription on Lactation in Postpartum Hypogalactia Rats with Liver-Qi Stagnation and Spleen Deficiency Syndrome: An Experimental Study |
| CHEN Baoyan,LI Kunyin,ZHEN Yuhua |
| (The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, China;The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510378, China) |
| Abstract: |
| Objective To explore the effect of liver-soothing and spleen-strengthening prescription on lactation in postpartum hypogalactia rats with liver-Qi stagnation and spleen deficiency syndrome.Methods A rat model of postpartum hypogalactia comorbid with liver-Qi stagnation and spleen deficiency syndrome was established by administration of bromocriptine mesylate solution and chronic restraint stress. A total of 60 Wistar rats were randomly divided into blank control group, model group, Western medicine control group, and traditional Chinese medicine groups (low, medium, and high doses), with 10 rats in each group. The effect of liver-soothing and spleen-strengthening prescription was evaluated by macroscopic representation, body mass, lactation volume per hour, open-field test, and D-xylose excretion rate of rats, as well as net weight gain per litter.Results Compared with the model group, the Western medicine control group and traditional Chinese medicine groups (low, medium, and high doses) had significantly improved macroscopic representation and significant increases in body mass, lactation volume per hour, number of horizontal and vertical movements, and D-xylose excretion rate of the rats, as well as net weight gain per litter (P<0.05), with the greatest improvements observed in the medium-dose traditional Chinese medicine group.Conclusion Liver-soothing and spleen-strengthening prescription can promote the lactation of postpartum hypogalactia rats with liver-Qi stagnation and spleen deficiency syndrome, and can improve the macroscopic representation, behavioral performance, and the function of the spleen and stomach. |
| Key words: liver-soothing and spleen-strengthening prescription postpartum hypogalactia liver-Qi stagnation and spleen deficiency syndrome animal model lactation volume |
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