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周代俊,何述金,何承东,周邦维,王宇红.九味肝泰片对D-氨基半乳糖所致大鼠急性肝损伤的保护作用[J].湖南中医药大学学报英文版,2018,38(10):1125-1128.[Click to copy
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| 九味肝泰片对D-氨基半乳糖所致大鼠急性肝损伤的保护作用 |
| 周代俊,何述金,何承东,周邦维,王宇红 |
| (湖南新汇制药股份有限公司, 湖南 长沙 410200;湖南中医药大学, 湖南 长沙 410208) |
| 摘要: |
| 目的 探讨九味肝泰片对D-氨基半乳糖（D-GalN）所致大鼠急性肝损伤的保护作用。方法 采用腹腔注射D-GalN的方法复制急性肝损伤大鼠模型，并随机分为6组：模型组，联苯双酯片组（13.5 mg/kg），九味肝泰胶囊组（0.4 g/kg），九味肝泰片高、中、低剂量组（0.8、0.4、0.2 g/kg），另设正常组。连续灌胃给药7 d后，采用生化分析法检测各组大鼠血清谷丙转氨酶（ALT）、谷草转氨酶（AST）活性和肝糖原含量，同时检测肝匀浆液中超氧化物歧化酶（SOD）、丙二醛（MDA）和谷胱甘肽过氧化物酶（GSH-Px）水平。结果 与正常组比较，模型组大鼠血清AST和ALT显著升高（P<0.01）；与模型组比较，九味肝泰片能明显降低肝损伤大鼠血清ALT、AST活性及肝组织MDA水平，提高肝糖原含量（P<0.05或P<0.01）；同时与九味肝泰胶囊比较，九味肝泰片还能明显降低GSH-Px活性（P<0.05）。结论 九味肝泰片对D-GalN所致急性肝损伤大鼠具有明显的保护作用，其作用机制可能与抗氧化有关，且部分指标效果优于九味肝泰胶囊。 |
| 关键词: 九味肝泰片 D-氨基半乳糖 急性肝损伤 保护作用 |
| DOI：10.3969/j.issn.1674-070X.2018.10.007 |
| Received:May 04, 2016 |
| 基金项目: |
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| Protective Effect of Jiuwei Gantai Tablet on Rats with Acute Liver Injury Induced by D-galactosamine |
| ZHOU Daijun,HE Shujin,HE Chengdong,ZHOU Bangwei,WANG Yuhong |
| (Hunan Xinhui Pharmaceutical Co., Ltd., Changsha, Hunan 410200, China;Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Objective To investigate the protective effect of Jiuwei Gantai Tablet on rats with liver injury induced by D-galactosamine (D-GalN). Methods A rat model of acute liver injury was established by intraperitoneal injection of D-GalN. The rats above were randomly divided into six groups:model group, bifendate tablet group (13.5 mg/kg), Jiuwei Gantai Capsule group (0.4 g/kg), and high-, medium-, and low-dose Jiuwei Gantai Tablet groups (0.8, 0.4, and 0.2 g/kg); meanwhile, a normal group was set. After 7 consecutive days of intragastric administration, the activities of alanine transaminase (ALT) and aspartate transaminase (AST) in serum and the liver glycogen content were measured by biochemical analysis; additionally, the levels of superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione peroxidase (GSH-Px) in liver homogenate were measured. Results The model group had significantly increased activities of ALT and AST compared with the normal group (P<0.01). The Jiuwei Gantai Tablet groups showed significantly reduced activities of ALT and AST in serum and MDA level in liver tissue, but significantly increased liver glycogen content, as compared with the model group (P<0.05 or P<0.01), as well as significantly reduced activity of GSH-PX compared with the Jiuwei Gantai Capsule group (P<0.05). Conclusion Jiuwei Gantai Tablet has obvious protective effects on rats with acute liver injury induced by D-GalN, the mechanism of which may be related to its antioxidation. Moreover, Jiuwei Gantai Tablet shows superior effects in improving certain indices compared with Jiuwei Gantai Capsule. |
| Key words: Jiuwei Gantai Tablet D-galactosamine acute liver injury protective effect |
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