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喻斌,杜珊,阳力,刘振杰,曾孟晖,毛一之.肝胃百合汤对慢性应激性胃溃疡模型小鼠的影响[J].湖南中医药大学学报英文版,2018,38(10):1115-1119.[Click to copy
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| 肝胃百合汤对慢性应激性胃溃疡模型小鼠的影响 |
| 喻斌,杜珊,阳力,刘振杰,曾孟晖,毛一之 |
| (湖南中医药大学第一附属医院, 湖南 长沙 410007;湖南中医药大学, 湖南 长沙 410208) |
| 摘要: |
| 目的 观察肝胃百合汤治疗慢性应激性胃溃疡的疗效。方法 将40只BALB/c小鼠随机分为空白组、模型组、肝胃百合汤组（中药组）、雷尼替丁组（西药组），空白组常规饲养，其余3组按照不可预知慢性应激方法造模，持续28 d；造模14 d后各组给予相应灌胃处理14 d；观察小鼠一般行为学、旷场实验、体质量变化，计算溃疡指数（ulcer index，UI）及溃疡抑制率、胃黏膜病理改变。结果 造模14 d后模型组小鼠行为学明显异常，旷场实验各项得分及体质量明显低于空白组，灌胃14 d后中药组小鼠一般行为改善，旷场实验各项得分及体质量与模型组对比明显上升；中药组UI低于模型组及西药组，且溃疡抑制率高于西药组；与空白组比，模型组小鼠胃黏膜可见散在糜烂及点状溃疡；与模型组比，西药组可见较多点状糜烂，未见明显溃疡，中药组仅见少量糜烂。结论 肝胃百合汤能减轻小鼠胃黏膜炎症，修复胃黏膜、促进溃疡愈合。 |
| 关键词: 慢性应激性胃溃疡 肝胃百合汤 肝胃气滞证 |
| DOI：10.3969/j.issn.1674-070X.2018.10.005 |
| Received:October 31, 2017 |
| 基金项目:湖南省中医药管理局重点课题（201512）。 |
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| Effect of Ganwei Baihe Decoction on a Mouse Model of Chronic Stress Gastric Ulcer |
| YU Bin,DU Shan,YANG Li,LIU Zhenjie,ZENG Menghui,MAO Yizhi |
| (The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China;Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Objective To observe the efficacy of Ganwei Baihe Decoction in the treatment of chronic stress gastric ulcer. Methods Forty BALB/c mice were randomly divided into blank group, model group, Ganwei Baihe Decoction (TCM) group, and ranitidine (WM) group. The blank group was given routine care. For the other three groups, a mouse model was established by unpredictable chronic stress for 28 days. At 14 days after model establishment, each group was given the corresponding drug by gavage for 14 days. The general behavior, open field test, and body mass change were observed. The ulcer index (UI), rate of ulcer inhibition, and pathological changes in the gastric mucosa were evaluated. Results At 14 days after model establishment, the model group showed obvious abnormal behavior; the model group also had significantly lower scores for each item of the open field test and significantly lower body mass than the blank group. After 14 days of drug administration by gavage, the general behavior of the TCM group was improved; the TCM group had significantly higher scores for each item of the open field test and significantly higher body mass than the model group; the TCM group had a significantly lower UI than the model group and the WM group; the rate of ulcer inhibition was significantly higher in the TCM group than in the WM group; compared with the blank group, the model group showed scattered erosion and punctate ulcer in the gastric mucosa; compared with the model group, the WM group showed more punctate erosion but no obvious ulcer in the gastric mucosa, while the TCM group showed only a small amount of erosion. Conclusion Ganwei Baihe Decoction can reduce inflammation of the gastric mucosa, repair the gastric mucosa, and promote ulcer healing. |
| Key words: chronic stress gastric ulcer Ganwei Baihe Decoction Qi-stagnation syndrome of liver and stomach |
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