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雷杰,郑琼莉.葱白提取物对大鼠急性心肌缺血损伤保护作用的研究[J].湖南中医药大学学报英文版,2018,38(7):746-749.[Click to copy
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| 葱白提取物对大鼠急性心肌缺血损伤保护作用的研究 |
| 雷杰,郑琼莉 |
| (武汉市中西医结合医院心血管内科, 湖北 武汉 430022) |
| 摘要: |
| 目的 观察葱白提取物对大鼠急性心肌缺血损伤的保护作用及可能的机制。方法 将40只大鼠随机分为假手术组、模型组、葱白提取物组、硝酸甘油组，每组10只，通过在体结扎冠状动脉前降支制备大鼠急性心肌缺血模型，使用HE染色后观察心肌组织病理形态学改变，采用ELISA法检测大鼠血清总抗氧化能力（T-AOC）、谷胱甘肽过氧化物酶（GSH-Px）和髓过氧化物酶（MPO）的活性及血清中丙二醛（MDA）、白介素-10（IL-10）、白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）水平。结果 与模型组比较，各治疗组均能提高血清中T-AOC、GSH-Px活性及IL-10水平，降低MDA、IL-6、TNF-α水平及MPO活性（P<0.01，P<0.05）。结论 葱白提取物有抗大鼠急性心肌缺血作用，其机制可能与抗氧化损伤和抑制炎症反应有关。 |
| 关键词: 葱白提取物 急性心肌缺血 保护作用 炎症反应 氧化损伤 |
| DOI：10.3969/j.issn.1674-070X.2018.07.007 |
| Received:September 24, 2017 |
| 基金项目:武汉市卫生计生办科研项目（WZ14A06）。 |
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| Protective Effect of Scallion Stalk Extract Against Acute Myocardial Ischemic Injury in Rats |
| LEI Jie,ZHENG Qiongli |
| (Department of Cardiovascular Medicine, Wuhan Hospital of Integrated Traditional Chinese and Western Medicine, Wuhan, Hubei 430022, China) |
| Abstract: |
| Objective To investigate the protective effect of scallion stalk extract against acute myocardial ischemic injury in rats and its possible mechanism. Methods A total of 40 rats were equally and randomly divided into sham-operation group, model group, scallion stalk extract group, and nitroglycerin group. An acute myocardial ischemia model was prepared by ligation of the anterior descending branch of the coronary artery in rats. The histopathological morphology of myocardium was observed by HE staining. Enzyme-linked immunosorbent assay was used to measure serum total antioxidant capacity (T-AOC), the activities of glutathione peroxidase (GSH-Px) and myeloperoxidase (MPO), and the serum levels of malondialdehyde (MDA), interleukin-10 (IL-10), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). Results Compared with the model group, the two treatment groups had significantly higher serum T-AOC, GSH-Px activity, and IL-10 level, and significantly lower levels of MDA, IL-6, and TNF-α and MPO activity (P<0.01, P<0.05). Conclusion Scallion stalk extract has a protective effect against acute myocardial ischemia and its mechanism may be related to anti-oxidative damage and inhibition of inflammatory response. |
| Key words: scallion stalk extract acute myocardial ischemia protective effect inflammatory response oxidative damage |
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