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王希斌,杨斌,刘华钢.两面针中木脂素化合物结晶-8对疼痛大鼠中枢PGE2、NO、MDA水平的影响[J].湖南中医药大学学报英文版,2018,38(7):743-745.[Click to copy
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| 两面针中木脂素化合物结晶-8对疼痛大鼠中枢PGE2、NO、MDA水平的影响 |
| 王希斌,杨斌,刘华钢 |
| (广西医科大学第一附属医院药学部, 广西 南宁 530021;广西医科大学药学院, 广西 南宁 530021) |
| 摘要: |
| 目的 观察两面针中木脂素化合物结晶-8（简称Crys-8）对甲醛致痛大鼠中枢一氧化氮（NO）、前列腺素E2（PGE2）、丙二醛（MDA）水平的影响。方法 建立福尔马林疼痛模型，并给予Crys-8治疗，采用比色法测定大鼠脑组织中的NO、PGE2、MDA水平。结果 模型组大鼠脑组织PGE2、NO、MDA分别为（0.82±0.09）A值，（17.53±4.50）μmol/L，（119.72±26.30） nmol/mL，与正常对照组比较，模型组可以显著升高中枢PGE2、NO、MDA表达（P<0.01），差异有统计学意义。Crys-8低剂量组PGE2、NO分别为（0.44±0.05）A值，（13.06±0.80）μmol/L，Crys-8高剂量组MDA为（74.14±16.89） nmol/mL，与模型组比较，Crys-8可以显著降低中枢PGE2、NO、MDA表达（P<0.05），差异有统计学意义。结论 Crys-8镇痛机制可能与抑制中枢的PGE2、NO、MDA的释放，提高其抗氧化能力有关。 |
| 关键词: 两面针 木脂素化合物 结晶-8 镇痛机制 一氧化氮 前列腺素E2 丙二醛 |
| DOI：10.3969/j.issn.1674-070X.2018.07.006 |
| Received:March 14, 2017 |
| 基金项目:高等学校博士学科点专项科研基金课题（20050598003）。 |
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| Effect of the Lignan Compound Crystal-8 from Zanthoxylum nitidum (Roxb.) DC. on the Expression of Prostaglandin E2, Nitric Oxide, and Malondialdehyde in Rats with Pain |
| WANG Xibin,YANG Bin,LIU Huagang |
| (Department of Pharmacy, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China;College of Pharmacy, Guangxi Medical University, Nanning, Guangxi 530021, China) |
| Abstract: |
| Objective To investigate the effect of crystal-8 (Crys-8), a lignan compound from Zanthoxylum nitidum (Roxb.) DC., on the levels of nitric oxide (NO), prostaglandin E2 (PGE2), and malondialdehyde (MDA) in the central nervous system in rats with pain caused by formaldehyde. Methods A model of pain caused by formaldehyde was established in rats, and Crys-8 treatment was given. Colorimetry was used to measure the levels of NO, PGE2, and MDA in the brain tissue of rats. Results Compared with the normal control group, the model group had significantly higher levels of PGE2 (0.82±0.09) A, NO (17.53±4.50) umol/L, and MDA (119.72±26.30 nmol/mL) in brain tissue (P<0.01). Compared with the model group, the low-dose Crys-8 group had significantly lower levels of PGE2 (0.441±0.05 A) and NO (13.06±0.8 umol/L) (P<0.05), and the high-dose Crys-8 group had a significantly lower level of MDA (74.14±16.89 nmol/mL) (P<0.05). Conclusion Crys-8 exerts an analgesic effect possibly by inhibiting the release of PGE2, NO, and MDA in the central nervous system and increasing their antioxidant capacity. |
| Key words: Zanthoxylum nitidum (Roxb.) DC. lignan compound crystal-8 analgesic mechanism nitric oxide prostaglandin E2 malondialdehyde |
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