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覃艮艳,张又玮,彭晓芳,王英,彭俊,彭清华.密蒙花颗粒对亚慢性毒性实验中SD大鼠血液生化指标的分析[J].湖南中医药大学学报英文版,2017,37(11):1188-1191.[Click to copy
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| 密蒙花颗粒对亚慢性毒性实验中SD大鼠血液生化指标的分析 |
| 覃艮艳,张又玮,彭晓芳,王英,彭俊,彭清华 |
| (湖南中医药大学, 湖南 长沙 410007) |
| 摘要: |
| 目的 观察密蒙花颗粒对SD大鼠的亚慢性毒性作用及其血液生化指标变化情况。方法 80只SD大鼠随机分为4组（雌雄各半），即空白对照组及密蒙花颗粒低、中、高剂量组，进行为期3个月的亚慢性毒理实验，其中3个给药组分别将密蒙花颗粒23.75 g、45 g、95 g溶于100 mL生理盐水中，灌胃体积为20 mL/kg，空白对照组予以同等灌胃体积生理盐水灌胃，观察各实验组及对照组血常规、谷丙转氨酶、谷草转氨酶、肌酐、尿素、总胆固醇、甘油三酯、葡萄糖、血钾、血钠、血氯、肌酸激酶等指标变化情况，从而进一步评价密蒙花颗粒对SD大鼠血液系统、肝脏、肾脏、心脏等的毒性作用。结果 密蒙花颗粒对SD大鼠血液生化相关指标无不良影响。结论 密蒙花颗粒对SD大鼠血液生化指标无明显慢性毒性反应，可在临床推广应用。 |
| 关键词: 密蒙花颗粒 亚慢性毒性实验 SD大鼠 血液指标 生化指标 |
| DOI：10.3969/j.issn.1674-070X.2017.11.005 |
| Received:May 30, 2017 |
| 基金项目:国家自然科学基金面上资助项目（30772824，81574031）；湖南省高层次卫生人才“225”工程培养项目资助；湖南省科技厅科研基金资助项目（2015SF2016-6）；湖南省发展改革委科研基金资助项目（湘发改投资[2014]658号）；长沙市科技计划重大专项（K1501014-31）；湖南中医药大学研究生创新项目（2016CX19）；国家中医药管理局中医眼科学重点学科建设项目；湖南省中医五官科学重点学科建设项目。 |
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| Sub-chronic Toxicity Study of Buddleja Officinalis Granules on Indexes of Hematology and Serum Biochemistry in SD Rats |
| QIN Genyan,ZHANG Youwei,PENG Xiaofang,WANG Ying,PENG Jun,PENG Qinghua |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Objective To observe the chronic toxicity effects of Buddleja Officinalis granules and the changes of indexes about hematology and serum biochemistry in SD rats. Methods 80 SD rats were randomly divided into 4 groups (male and female are fifty-fifty), including the control group and experiment groups. Experiment groups were divided into low, middle and high dose which were fed with 23.75 g, 45 g and 95 g of Buddleja Officinalis granules mixed with 100 mL physiological saline for the three months' subchronic toxicity test. The gavage administration was 20 mL/kg, and the control group was given equivalent physiological saline. The indexes of white blood cell, red blood cell, hemoglobin, hematokrit, Mch, RDW-CV, blood platelet, glutamic-pyruvic transaminase, glutamic-oxalacetic transaminase, creatinine, urea, creatine kinase, kalium, serum sodium, blood chloride, cholesterol total, glycerin trimyristate,blood glucose were observed in four groups to evaluate the toxic and side effect of buddleja Officinalis granules on blood system, liver, kidney, heart. Results Buddleja Officinalis granules had no bad influence on the indexes of hematology and serum biochemistry. Conclusion Buddleja Officinalis Granules have no chronic toxicity on SD rats and can be extended to application in clinic. |
| Key words: Buddleja Officinalis granules chronic toxicity experiment SD rats hematology biochemical index |
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