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李春晖.益气活血汤联合西药治疗冠心病心绞痛疗效及对血清炎症因子水平的影响[J].湖南中医药大学学报英文版,2017,37(9):969-972.[Click to copy
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| 益气活血汤联合西药治疗冠心病心绞痛疗效及对血清炎症因子水平的影响 |
| 李春晖 |
| (土家族苗族自治州巴东县人民医院药剂科, 湖北 恩施 444300) |
| 摘要: |
| 目的 探讨益气活血汤联合西药治疗冠心病心绞痛的疗效，并分析其对血清炎症因子水平的影响。方法 将冠心病心绞痛患者120例随机分为两组，每组60例。对照组患者给予西药常规治疗，观察组患者在对照组的基础上加用自拟益气活血汤。连续治疗8周后，对两组患者的疗效、血脂水平和血清炎症因子水平进行比较和分析。结果 治疗8周后，观察组的总有效率为90.0%，显著高于对照组（78.3%），差异具有统计学意义（P<0.05）；观察组的甘油三酯、总胆固醇和低密度脂蛋白水平均显著低于对照组，而高密度脂蛋白水平显著高于对照组，差异具有统计学意义（P<0.05）；观察组的超敏C-反应蛋白（hs-CRP）、肿瘤坏死因子（TNF-α）和白细胞介素6（IL-6）水平均显著低于对照组，差异具有统计学意义（P<0.05）。结论 益气活血汤联合西药治疗冠心病心绞痛疗效显著，患者血脂明显改善，血清炎症因子水平显著降低，值得临床推广。 |
| 关键词: 冠心病心绞痛 益气活血汤 血清炎症因子 临床研究 |
| DOI：10.3969/j.issn.1674-070X.2017.09.013 |
| Received:April 18, 2017 |
| 基金项目: |
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| Effect of Yiqi Huoxue Decoction Combined with Western Medicine on Serum Inflammatory Factors and Angina Pectoris of Coronary Heart Disease |
| LI Chunhui |
| ((Department of Pharmacy, Badong People's Hospital in Tujia and Miao Autonomous Prefecture, Enshi, Hubei 443000, China) |
| Abstract: |
| Objective To explore the efficacy of Yiqi Huoxue decoction combined with Western medicine in the treatment of angina pectoris of coronary heart disease and its effect on level of serum inflammatory factors. Methods The 120 patients with angina pectoris of coronary heart disease were randomly divided into two groups, 60 cases in each group. The control group was treated with conventional Western medicine treatment, and the patients in the observation group were given self-made Yiqi Huoxue decoction based on the control group. After 8 weeks of treatment, the efficacy, blood lipid level and serum inflammatory factor levels in the two groups were compared and analyzed. Results After 8 weeks of treatment, the total effective rate of the observation group was 90%, which was significantly higher than the control group (78.3%), the difference was statistically significant (P<0.05). The triglycerides, total cholesterol and low density lipoprotein levels in observation group were significantly lower than the control group, and high density lipoprotein level were significantly higher than the control group, the differences were statistically significant (P<0.05). The high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) levels in the observation group were significantly lower than the control group, the differences were statistically significant (P<0.05). Conclusion Yiqi Huoxue decoction combined with Western medicine could show obvious effect on angina pectoris of coronary heart disease, could improve blood lipid levels of patients, and lower the serum inflammatory factor levels significantly, which is worthy of clinical promotion. |
| Key words: angina pectoris of coronary heart disease Yiqi Huoxue Decoction serum inflammatory factors clinical study |
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