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陈宝清,郭岱炯,杨玉峰,钱方.丹白涂膜剂对黄褐斑患者皮肤屏障功能修复的临床研究[J].湖南中医药大学学报英文版,2017,37(9):973-976.[Click to copy
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| 丹白涂膜剂对黄褐斑患者皮肤屏障功能修复的临床研究 |
| 陈宝清,郭岱炯,杨玉峰,钱方 |
| (深圳市中医院皮肤科, 广东 深圳 518033) |
| 摘要: |
| 目的 观察丹白涂膜剂治疗黄褐斑的临床疗效及对患者皮肤屏障功能的修复作用。方法 将100例患者随机分为治疗组和对照组各50例。治疗组患者涂抹丹白涂膜剂，每晚1次；对照组涂抹2%氢醌乳膏，每晚1次。治疗3个月后评定分析两组的临床疗效；观察两组患者治疗前、治疗1个月、治疗3个月后的面部皮肤角质层含水量、经皮失水值（TEWL）、黑色素量。结果 治疗3个月后，治疗组总显效率为68.0%，对照组为52.0%，两组差异有统计学意义（P<0.05）。治疗1个月时，治疗组皮肤角质层含水量较治疗前显著增加、TEWL值显著下降（P<0.05），对照组皮肤角质层含水量较治疗前显著下降、TEWL值显著升高（P<0.05），且两组间比较差异有统计学意义（P<0.05）；治疗3个月时，治疗组患者皮肤角质层含水量较治疗1个月时显著增加、TEWL值显著下降（P<0.05），对照组患者皮肤角质层含水量、TEWL值较治疗1个月时差异无统计学意义（P>0.05），且治疗组患者皮肤角质层含水量显著高于对照组（P<0.05），TEWL值显著低于对照组（P<0.05）；两组皮肤黑色素量均较治疗前下降（P<0.05），两组间比较差异无统计学意义（P>0.05）。结论 丹白涂膜剂治疗黄褐斑比2%氢醌乳膏疗效更优，且对患者皮损部位的皮肤屏障功能具有更好的修复作用。 |
| 关键词: 黄褐斑 丹白涂膜剂 皮肤屏障功能 角质层含水量 经皮失水值 黑色素量 |
| DOI：10.3969/j.issn.1674-070X.2017.09.014 |
| Received:April 19, 2017 |
| 基金项目:广东省中医药强省科研课题（20141241）。 |
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| Repairing Effects of Danbai Coating Agent on Skin Barrier Function in Patients with Chloasma |
| CHEN Baoqing,GUO Daijiong,YANG Yufeng,QIAN Fang |
| (Department of Dermatology, Shenzhen TCM Hospital, Shenzhen, Guangdong 518033, China) |
| Abstract: |
| Objective To observe the clinical effect of Danbai coating agent in the treatment of chloasma and the repair of skin barrier function. Methods 100 patients were randomly divided into treatment group and control group, 50 cases in each group. Patients in the treatment group were smeared Danbai coating agent every night, once daily. The control group was coated with 2% hydroquinone cream, once a night. After 3 months of treatment, the clinical efficacy of the two groups was evaluated and analyzed. The skin water content, TEWL value and skin melanin content of the patients in the two groups before treatment, after 1 month and 3 months of treatment were analyzed. Results After 3 months of treatment, the effective rate of the treatment group was 68%, and that of the control group was about 52%. The difference between the two groups was significant (P<0.05). After one month of treatment, the water content of stratum corneum significantly increased and the TEWL value decreased significantly in the treatment group (P<0.05). The stratum corneum water content in the control group decreased significantly, and the TEWL value increased significantly (P<0.05). There was significant difference between the two groups (P<0.05). After 3 months of treatment, the skin corneum water content in treatment group significantly increased compared with the treatment for 1 month, TEWL significantly decreased (P<0.05). In the control group, the stratum corneum water content of the skin and TEWL value had no significant difference than treatment for 1 month (P>0.05). The skin corneum water content of the treatment group was significantly higher than that of the control group (P<0.05), the TEWL value was significantly lower than that of the control group (P<0.05). The amount of skin melanin in the two groups decreased than before treatment, and there was no significant difference between the two groups (P>0.05). Conclusion Danbai coating agent shows better effect than 2% hydroquinone cream in treatment of chloasma and better repairing effect on the skin barrier function of patients. |
| Key words: chloasma Danbai coating agent skin barrier function water content of cuticle percutaneous losing water amount of melanin |
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