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魏高文,魏歆然,裴异,肖作为,朱旭,刘芸青,陈书,裴芸.蜂胶类黄酮对糖尿病合并肺结核患者外周血WBC与T淋巴细胞亚群的影响[J].湖南中医药大学学报英文版,2017,37(8):891-894.[Click to copy
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| This paper
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| 蜂胶类黄酮对糖尿病合并肺结核患者外周血WBC与T淋巴细胞亚群的影响 |
| 魏高文,魏歆然,裴异,肖作为,朱旭,刘芸青,陈书,裴芸 |
| (湖南中医药大学, 湖南 长沙 410208;长沙市中心医院, 湖南 长沙 410004) |
| 摘要: |
| 目的 探讨蜂胶类黄酮对糖尿病合并肺结核（diabetes mellitus complicated with pulmonary tuberculosis,DM-PTB）患者外周血中WBC与T淋巴细胞亚群的影响。方法 以DM-PTB患者120人为对象，利用随机数字表采用完全随机法分成A（蜂胶黄酮1 000 mg/d）、B（蜂胶黄酮2 000 mg/d）、C（条件对照）三组，每组40人，观察6个月，比较综合治疗前后白细胞计数（WBC）及分类（淋巴细胞L和中性粒细胞N）、T淋巴细胞亚群CD3+、CD4+、CD8+数量及CD4+/CD8+比值的变化，并比较组内前后差异和组间差异。结果 三组7项观测指标自身前后配对差值（治疗后-治疗前）的均数比较Hotelling T2=515.359，P=0.000；治疗7项观测指标差别Wilks λ=0.017，P=0.000，其中多重比较结果为WBC的B组大于A与C组，L的B组> A组> C组，N的B组大于A与C组，CD3+的B 与A组大于C组，CD4+的B组>A组>C组，CD4+/CD8+比值多重比较结果为B 与A组大于C组。结论 蜂胶类黄酮能提高DM-PTB患者的细胞免疫水平。 |
| 关键词: 蜂胶类黄酮 DM-PTB WBC T淋巴细胞亚群 细胞免疫 |
| DOI：10.3969/j.issn.1674-070X.2017.08.019 |
| Received:September 17, 2016 |
| 基金项目:湖南省自然科学基金项目（14JJ2112）。 |
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| Effect of Propolis Flavonoids on WBC and T lymphocyte Subsets in Peripheral Blood of Patients with Diabetes Mellitus Complicated with Pulmonary Tuberculosis |
| WEI Gaowen,WEI Xinran,PEI Yi,XIAO Zuowei,ZHU Xu,LIU Yunqing,CHEN Shu,PEI Yun |
| (Hunan University of Chinese Medcine, Changsha, Hunan 410208, China;Changsha Central Hospital, Changsha, Hunan 410004, China) |
| Abstract: |
| Objective To investigate the effect of propolis flavonoids on the level of the WBC and T lymphocyte subsets in peripheral blood of patients with diabetes mellitus complicated with pulmonary tuberculosis (DM-PTB). Methods The 120 DM-PTB patients were randomly divided into group A (propolis flavonoids 1 000 mg/d), group B (propolis flavonoids 2 000 mg/d), group C (control), 40 cases in each group. The WBC count and classification (lymphocyte L and neutrophil N), T lymphocyte subsets CD3+, CD4+, CD8+ and CD4+/CD8+ ratio in within and between groups were compared. Results The 7 sets of indicators before and after the treatment in the three groups were compared, Hotelling T2=515.359, P=0.000. The 7 sets of indicators after treatment were tested, Wilks λ=0.017,P=0.000. Multiple comparison results showed that WBC: group A > group B and group C, L: group B >group A >group C, N: group B > group A and group C, CD3+: group A and B >group C, CD4+: group B > group A > group C, CD4+/CD8+ ratio: group A and B > group C. Conclusion Propolis flavonoids can enhance the cellular immunity of DM-PTB patients. |
| Key words: propolis flavonoids WBC T lymphocyte subsets cellular immunity |
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