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李克营,杨芳.苓桂术甘配方颗粒治疗慢性心力衰竭（心肾阳虚证）的临床观察[J].湖南中医药大学学报英文版,2017,37(8):895-899.[Click to copy
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| 苓桂术甘配方颗粒治疗慢性心力衰竭（心肾阳虚证）的临床观察 |
| 李克营,杨芳 |
| (衡南县人民医院, 湖南 衡阳 421100;湖南中医药大学, 湖南 长沙 410208) |
| 摘要: |
| 目的 观察苓桂术甘配方颗粒治疗慢性心力衰竭（心肾阳虚证）的临床疗效及治疗结束后3月内的复发率情况。方法 将60例符合慢性心力衰竭Ⅱ-Ⅲ级（心肾阳虚证）诊断标准的患者随机分为中药配方颗粒治疗组、中药饮片治疗组与对照组，每组20例，中药配方颗粒组予西药常规治疗加苓桂术甘颗粒，中药饮片组予西药常规治疗加苓桂术甘饮片，对照组单予西药常规治疗，疗程均为两周。观察治疗前后患者临床症状、总有效率、左室射血分数（LVEF）、血浆脑尿钠肽（brain natriuretic peptide,BNP）的变化及治疗结束后3个月内复发率情况。结果 治疗2周后，中药配方颗粒组患者心功能改善总有效率为95%，中医证候改善总有效率为85%，复发率为10%，与对照组比较，差异具有统计学意义（P<0.025）；治疗后中药配方颗粒组左室射血分数（LVEF）显著提高、血液中BNP浓度明显降低（P<0.01）；中药配方颗粒组与饮片治疗组差异无统计学意义（P>0.05），中药配方颗粒组与饮片组疗效相当。结论 苓桂术甘配方颗粒可有效缓解慢性心力衰竭Ⅱ-Ⅲ级（心肾阳虚证）患者的中医证候，改善左室收缩功能,提高左室射血分数,明显降低血浆BNP含量,中西医结合治疗较单纯西药治疗副作用少,3个月内复发率低, 服用方便，临床安全性及依从性更好。 |
| 关键词: 慢性心力衰竭 苓桂术甘配方颗粒 心肾阳虚证 |
| DOI：10.3969/j.issn.1674-070X.2017.08.020 |
| Received:November 30, 2015 |
| 基金项目:湖南省研究生创新研究计划项目（CX2015B316）。 |
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| Clinical Effect of Linggui Zhugan Formula Granule on Chronic Heart Failure with Heart-Kidney Yang Deficiency Syndrome |
| LI Keying,YANG Fang |
| (Hengnan County People's Hospital, Hengyang, Hunan 421100, China;Hunan University of Chinese Medcine, Changsha, Hunan 410208, China) |
| Abstract: |
| Objective To observe the clinical effect and the recurrence rate in 3 months of Linggui Zhugan formula granule on chronic heart failure with heart-kidney Yang deficiency syndrome. Methods 60 patients were randomly divided into Chinese medicinal ganule group treated with Linggui Zhugan formula granule combined with Western medicine conventional therapy, Chinese medicinal decoction pieces group treated with Linggui Zhugan decoction pieces combined with Western medicine conventional therapy, control group treated with routine Western Medicine, the treatment course was for 2 weeks, 20 cases in each group. The clinical symptoms, total effective rate, left ventricular ejection fraction(LVEF), plasma brain natriuetic peptide (BNP), and the recurrence rate in 3 months were observed before and after treatment. Results After treatment for 2 weeks, compared with the control group, the total effective rate in Chinese medicine formula granule group was 95%, the effective rate of Chinese medicine syndrome was 85%, and the recurrence rate was 10% in formula granule group, there were significant differences between the two groups (P<0.05). The LVEF in Chinese medicine formula granule group significantly increased and BNP level decreased (P<0.01), there was no statistically significant differences between the Chinese medicine granule group and decoction pieces group (P>0.05). Conclusion Linggui Zhugan formula granule could effectively relieve chronic heart failure II-III with heart-kidney deficiency syndrome, improve left ventricular systolic function, increase left ventricular ejection fraction, reduce BNP content in plasma, and the recurrence rate in 3 months is low. Combination of TCM and Western medicine shows less side effects, good clinical safety and compliance. |
| Key words: chronic heart failure Linggui Zhugan formula granule heart-kidney Yang deficiency syndrome |
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