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周日宝,刘畅宇,彭美晨,王朝晖,刘湘丹.加兰他敏合成途径的研究进展[J].湖南中医药大学学报英文版,2016,36(12):85-90.[Click to copy
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| 加兰他敏合成途径的研究进展 |
| 周日宝,刘畅宇,彭美晨,王朝晖,刘湘丹 |
| (湖南中医药大学药学院, 湖南 长沙 410208) |
| 摘要: |
| 加兰他敏是一种广泛用于治疗阿尔茨海默氏症等疾病的药物，但研究发现，植物中加兰他敏含量极少，故科研人员一直致力于加兰他敏的合成研究。迄今为止，研究工作者已提出多种加兰他敏化学合成策略，但因其化学合成方法存在产率低、成本高、步骤复杂等诸多缺陷，不利于投入实际生产，探索其生物合成途径是目前最有效替代办法。本文综述了近年来加兰他敏合成的相关研究，且着重介绍了其生物合成途径及其相关酶研究进展，并对其后续研究进行展望。 |
| 关键词: 加兰他敏 生物合成途径 关键酶 基因调控 石蒜 |
| DOI：10.3969/j.issn.1674-070X.2016.12.021 |
| Received:July 06, 2016 |
| 基金项目:湖南省科技厅（2015SK2015）；国家中医药管理局“药用植物学”重点学科资助（国中医药发[2009]30号）；湖南省科技厅（2015NK2153）；湖南省“中药学”重点学科建设项目资助（湘教通[2011]76号）；湖湘中药资源保护与利用协同创新中心（湘教通[2015]351号）。 |
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| Advances in the Synthesis Pathways of Galanthamine |
| ZHOU Ribao,LIU Changyu,PENG Meichen,WANG Zhaohui,LIU Xiangdan |
| (School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Galanthamine is a drug that is widely used in the treatment of Alzheimer's disease and etc. But according to the studies, the extraction yield of galanthamine in natural plants is very limited, researchers have studied on the synthesis of galanthamine. So far, a variety of chemical synthesis strategies were proposed. However, due to the defects of the current chemical synthesis, such as low yield, high cost, complicated steps and etc, the methods are not conducive to practical production, at present, the most effective alternative is to explore the biosynthetic methods for galanthamine. The review summarizes the research advances in the synthesis of galantamine, and emphatically introduces the biosynthesis and synthesis-related enzymes of galantamine, the further study prospects of galantamine's synthesis are expected. |
| Key words: galanthamine biosynthetic pathway key enzyme gene control Lycoris radiata (L'Her.) Herb. |
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