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李黎,孙燕,廖怀章,刘绪银,肖黎.活血化瘀利水方对大鼠急性软组织损伤模型血清IL-6、组胺影响的实验研究[J].湖南中医药大学学报英文版,2016,36(3):21-23.[Click to copy
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| 活血化瘀利水方对大鼠急性软组织损伤模型血清IL-6、组胺影响的实验研究 |
| 李黎,孙燕,廖怀章,刘绪银,肖黎 |
| (正大邵阳骨伤科医院, 湖南 邵阳 422900) |
| 摘要: |
| 目的 通过利用活血化瘀利水方对急性软组织损伤大鼠血清IL-6、组胺影响的实验研究，探讨活血化瘀利水方对急性软组织损伤修复的机制。方法 将60只大鼠随机分为6组，即正常组、模型组、伤科跌打片组、活血化瘀利水低、中、高剂量组，除正常组外，余5组通过打击法造成急性软组织损伤模型，连续给药7 d后测定大鼠血清IL-6、组胺含量。结果 活血化瘀利水方组能够明显抑制急性软组织损伤大鼠血清IL-6、组胺的表达，与模型组比较有统计学意义（P<0.05），且其抑制作用与药物剂量相关，高剂量组抑制效果优于阳性药物组。结论 活血化瘀利水方对损伤局部炎症反应具有抑制作用，从而发挥对急性软组织损伤动物模型的治疗作用。 |
| 关键词: 急性软组织损伤 活血化瘀利水方 IL-6 组胺 当归 白茅根 茯苓 |
| DOI：10.3969/j.issn.1674-070X.2016.03.006 |
| Received:November 28, 2015 |
| 基金项目:湖南省中医药科研计划项目（2014127）。 |
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| Effects of Huoxue Huayu Lishui Prescriptionon on Serum IL-6 and Histamine in the Treatment of Acute Soft Tissue Injury Rat Models |
| LI Li,SUN Yan,LIAO Huaizhang,LIU Xuyin,XIAO Li |
| (Zhengda Shaoyang Orthopedics Hospital, Shaoyang, Hunan 422900, China) |
| Abstract: |
| Objective To observe the effect of Huoxue Huayu Lishui prescription on IL-6 and histamine level in blood of acute soft tissue injury rats. Methods 60 rats were randomly divided into 6 groups:the normal group, model group, Shangke Dieda tablet groou, low, medium and high dose of Huoxue Huayu Lishui prescription groups. In addition to the normal group, the rats in other 5 groups were made as acute soft tissue injury models by the method of hitting. After continuous medication for 7 days, serum IL-6 and histamine levels in rats were determinated. Results Huoxue Huayu Lishui prescription showed obvious inhibitory effect on the expression of serum IL-6 and histamine in acute soft tissue injury rats, which have significant differences comparing with the model group. Its inhibition exhibited positive correlation with the dose of prescription, while the effect of high dose group was better than that in positive drug group. Conclusion Huoxue Huayu Lishui prescription, which play a role in treatment of acute soft tissue injury animal models, shows inhibitory effect on local inflammatory response to injury. |
| Key words: acute soft tissue injury Huoxue Huayu Lishui prescription IL-6 histamine Angelica sinensis Rhizoma Imperatae Poria cocos |
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