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陈斌，彭建平，张涛，孙克伟，彭杰，祁双林.健脾、补肾与健脾补肾三法对慢性乙型肝炎患者外周血T细胞功能的影响[J].湖南中医药大学学报英文版,2011,31(11):48-51.[Click to copy
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| 健脾、补肾与健脾补肾三法对慢性乙型肝炎患者外周血T细胞功能的影响 |
| 陈斌，彭建平，张涛，孙克伟，彭杰，祁双林 |
| (1湖南中医药大学第一附属医院，湖南长沙410007;2湖南中医药大学，湖南长沙410208) |
| 摘要: |
| 目的比较健脾法、补肾法和健脾补肾法对慢性乙型肝炎患者外周血T细胞功能的影响、方法收集24例慢性乙型肝炎患者和10例健康人的抗凝外周静脉血，分离外周血单个核细胞(PBMCa)，进一步分离提取培养T细胞，采用大鼠健脾、补肾和健脾补肾药物血装进行千预检%}}J T细胞亚群CD3',CD4',CD8+及CD28+分子的表达结果3组药物血装千预后CD4+分子表达率升高}P<0.05), CD8+分子表达率降低}P<0.05)，补肾组药物血装千预后CD3+表达率升高(P<0.05)，补肾组和健脾补肾组药物血装千预后CD28+分子表达率升高(P<0.05)〔结论健脾法、补肾法和健脾补肾法均能调节慢性乙型肝炎患者T细胞免疫功能，补肾法对慢乙肝患者T细胞功能的影响更为显著、 |
| 关键词: 漫性乙型肝炎 补肾法 健脾法 补肾健脾法 T细胞 |
| DOI： |
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| 基金项目:国家自然科学基金资助项日(81072779);湖南省教育厅科研基金资助项日(08C619) |
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| Effects of tonifying kidney, strengthening spleen and tonifying spleenkidney on peripheral blood T cells in chronic hepatitis patients |
| CHEN Bin'，PENG Jian-ping'，ZHANG Tao'，SUN Ke-wei'*，PENG Jie'，QI Shuang-lint |
| (1. First Affiliated Hospital, TCM University of Hunan, Changsha, Hunan 410007, China;2. TCM University of Hunan, Changsha, Hunan 410208, China) |
| Abstract: |
| Objective To compare the effects of of tonifying kidney,strengthening spleen and tonifying spleen-kidney on peripheral blood T cells in chronic hepatitis patients. Methods The peripheral blood anticoagulant from 24 patients with chronic hepatitis and 10 healthy people were separated for peripheral blood mononuclear cells (PBMCs), further, T cells were extracted, separted and cultured, then, the T cells were interfered by plasma with the three groups of Chinese medicines. The expression of CD3'，CD4'，CD8' and CD28' in T cells were detected. Results After intervened by the medicated plasma including three groups of medicines, the levels of CD4' expression were higher(P<0.05), the levels of CD8' expression were lower(P<0.05); after intervened by medicated plasma including tonifying kidney medicines, the level of CD3' expression were higher;after intervened by medicated plasma including tonifying kidney and tonifying spleen -kidney medicines, the levels of CD28' expression were higher(P<0.05). Conclusion All the three groups of medicines can regulate T cells in patients, and the tonifying kidney method is more signicant. |
| Key words: chronic hepatitis B tonifyin} kidney strengthening spleen tonifying kidney and spleen T cells |
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