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伍参荣，蔡锐，李珊，申可佳，贾本真，李芳荣.黄葵素对结核分枝杆菌的抑杀作用研究[J].湖南中医药大学学报英文版,2011,31(11):19-23.[Click to copy
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| 黄葵素对结核分枝杆菌的抑杀作用研究 |
| 伍参荣，蔡锐，李珊，申可佳，贾本真，李芳荣 |
| (1.湖南中医药大学病原免疫学教研室，湖南长沙410208;2.湖南中医药研究院，湖南长沙410006) |
| 摘要: |
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| 关键词: 黄葵素 结核分枝杆菌川"鼠 抗菌活性 |
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| 基金项目: |
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| Effects of Huangkuisu on killing and suppressing mycobacterium tuberculosis |
| WU Can-rong, CAI Rui, LI Shan, SHEN Ke-_jia, JIA Ben-zheng, LI Fang-rong |
| (1. TCM University of Hunan, Changsha, Hunan 410208, China;2. Hunan Academy of Chinese Medicine, Changsha, Hunan 410006,China)) |
| Abstract: |
| Objective To evaluate the antituberculous activities of Huangkuisu (HISS). Meth-ods lOStandard human strains of mycobacterium tuberculosis (H37RV) and multi-drug resistant TBstrainswere inoculated in different concentrations of HISS, blank control and positive TB drug culture medium[()observe the growth of mycobacterium tuberculosis and evaluate the antibacterial activity in vitro.②Certain number of standard strains of Mycobacterium tuberculosis H37Rv and drug-resistant strains were injected into the tail vein[()establish a mouse model of mycobacterium tuberculosis infection. The mice were randomly divided into treatment group, rifampicin, HISS treatment group treated lasting for 6 weeks; the control group was given normal saline. The antibacterial activity in vivo were evaluated[()compare the treatment results according[()the pathological changes in lung and spleen tissues (HE staining and acid-fast staining) and charging amount of bacteria. Results lOthe bactreial colonies were grew normally in model group, but were not grew in |
| Key words: Huangkuisu (HISS) mycobacterium tuberculosis mice pharmacodynamics |
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