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段春艳’.陈元2.李定祥2.邓奕辉2*.滋阴活血解毒方对局灶性脑缺血模型大鼠
血清中IL-1(3,IL-8,TNF-。含量的影响[J].湖南中医药大学学报英文版,2011,31(1):36-39.[Click to copy
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| 滋阴活血解毒方对局灶性脑缺血模型大鼠
血清中IL-1(3,IL-8,TNF-。含量的影响 |
| 段春艳’.陈元2.李定祥2.邓奕辉2* |
| (1湖南中医药大学2008级硕士研究生班，湖南长沙410007;2湖南中医药大学，湖南长沙410007) |
| 摘要: |
| 〔摘要〕目的观察滋阴活血解毒饮片及超微方对大鼠局灶性脑缺血后白细胞介素一1日(IL-1日)、白细胞介素-
8(IL-8)、肿瘤坏死因子一。(TNF-a)含量的影响、方法将25只大鼠随机分为假手术组、模型组、滋阴活血解毒方饮
片组(以卜简称饮片组)、滋阴活血解毒方超微组(以卜简称超微组)、阿加曲班组，每组5只、大脑中动脉线栓法复
制局灶性脑缺血模型，进行神经功能评分〔造模成功后7d，用TTC染色法测定脑梗死范围，用Motic Med6.0数码
图像分析系统分析脑梗死面积〔采用ELISA法测定大鼠血清IL-1日,IL-8 ,TNF-。的含量〔结果饮片组、超微组及
阿加曲班组大鼠脑梗死体积比均明显低于模型组，差异具有统计学意义(P<0.01) ;模型组血清IL-1日,IL-8,TNF-a
含量明显高于假手术组(P<0.01)，饮片组、超微组、阿加曲班组均能明显降低大鼠血清IL-1日、IL-8 , TNF-a含量，
与模型组比较，差异均有统计学意义(P<0.01)、结论滋阴活血解毒方能减小脑梗死面积，抑制炎性因子的表达，降
低脑缺血所致的脑损伤、 |
| 关键词: 滋阴活血解毒方 局灶性脑缺血 脑梗死体积比 IL-1队IL-8 TNF-a 大鼠 熟地 构祀 黄茂 |
| DOI： |
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| 基金项目:湖南省科技厅资助项日(2009FJ3140);湖南省教育厅青午基金项日(08B005) |
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| Effects of Ziyin Huoxue Jiedu decoction on contentsof serum IL-1p，IL-8 and TNF-a in local cerebral infarction in rats |
| DUAN Chun-yan，CHEN Yuan，LI Ding-xiang，DENG Yi-hui |
| ((TCM University of Hunan，Changsha，Hunan 410007，China) |
| Abstract: |
| (Abstract〕 Objective To observe the different effects of traditional Ziyin Huoxue
Jiedu decoction and its ultra-micro pieces decoction on the serum contents of IL-1(3, IL-8 and
TNF-cx in rats. Methods 25 rats were randomly divided into the sham一(operated, model, tradi-
tional Ziyin Huoxue Jiedu decoction (TZHJD), ultra-micro pieces Ziyin Huoxue Jiedu decoction
(UZHJD) and Argatroban Injection(AI) groups, 5 rats per group. The models were reproduced by
occluded middle cerebral artery. The neurological function were evaluated. After modeling
7 days, the cerebral infarct range was determined by TTC, the cerebral infarct area was ana-
lyzied by Motic Med6.0 digital image analysis system, and the serum content of IL一1 [3, IL-8
and TNF一。were measured by enzyme -linked immunosorbent assay (ELISA)methods. Results
Compared with model group, infarct volum ratio in all the TZHJC, UZHJD and AI groups were
lower (P<0.01)，the content of IL一1 [3, L-8 and TNF一。in the model group was much higher than that in the sham-operated group(P<0.01), while the contents of IL-1(3, IL-8 and TNF-cx in
all the TZHJC, UZHJD and AI groups were lower than that in the model group (P<0.01).Con-
elusion Zinyin Huoxue Jiedu decoction is effective[()二、luce cerebral infarct size，restrain in-
flammatory factor expression, and二、luce the cerebral injury caused by cerebral ischemia. |
| Key words: (Key words〕 Ziyin Huoxue Jiedu decoction local cerebral ischemia infarct volume ratio IL-1(3 IL-8 TNF-cx rats prepared radix rehmanniae wolfberry Radix astragals |
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