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李天禹’，何清湖2*，卢芳国2，刘朝圣2*，万胜.雄性“肾阳虚”亚健康大鼠模型的研究[J].湖南中医药大学学报英文版,2011,31(1):22-24.[Click to copy
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| 雄性“肾阳虚”亚健康大鼠模型的研究 |
| 李天禹’，何清湖2*，卢芳国2，刘朝圣2*，万胜 |
| (C1遵义医学院附属医院中医科，贵州遵义410208;2湖南中医药大学，湖南长沙410208
3湖南中医药大学2008级博士研究生班，湖南长沙410208)) |
| 摘要: |
| 〔摘要〕目的研究雄性“’肾阳虚”亚健康大鼠模型，为调理男性肾阳虚亚健康找寻科学配方〔方法控制用药剂
量及灌胃时间，用维生素B,建立雄性“’肾阳虚”亚健康大鼠模型，检测腺垂体一辜丸轴激素、氧化损伤因子及抗氧化
损伤因子、辜丸组织微细结构作为判断亚健康组织学依据〔结果与正常大鼠相比较，模型大鼠血清FSH,LH,T均
降低，均有统计学意义;模型大鼠rfn.清SOD卜降，差异有统计学意义(P<0.05 ) ; MDA增加，差异有统计学意义(P<
0.01) ;模型大鼠辜丸组织曲细精管规则，管腔变大，精子尾部有融合现象，生精细胞层次减少，排列较紊乱，出现空
泡现象结论运用维生素B,建立的雄性“’肾阳虚”亚健康大鼠模型成功 |
| 关键词: 肾阳虚 亚健康 维生素B, 大鼠 |
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| 基金项目:湖南省教育厅科学研究青午项日(08B057);湖南省研究生科研创新基金项日(CX2009B173) |
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| Study on sub-health model of male Kidney-yang deficiency in rats |
| LI Tian-yu, HE Qing-hu, LU Fang-guo, LIU Chao-seng, WAN Sheng |
| (Affiliated Hospital, Zunyi Medical College, Zunyi, Guizhou 563000, China) |
| Abstract: |
| [Abstract] Objective To cxpl<)二[he sub-health model of male Kidney-yang deficiency in
rats and look for a method for regulation of male Kidney-yang deficiency in human. Method
Vitamin BQ was used[()set up the sub-health rats model of male Kidney-yang deficiency, the
level of anterior pituitary一[esticulus axle hormone, the content of oxidative damage factors and
anti一(>xidative damage factors, the fine structure of testicle tissue were detected
[()measure histological baseness in sub-health condition. Result Compared with normal rats, the
levels of FSH, LH, T and SOD were decreased(P<0.05), and content of MDA was increased(P<
0.01). the seminiferous tubule structure of testicle tissue was neat but lumen was expanded.
There were the part-fusing in sperm tail, spermatogenic cell-staging decreased, ranged abnormal
and existed the vacuolus. Conclusion Vitamin BQ can be used[()establish the
sub-health model. |
| Key words: Kidney-yang deficiency sub-health vitamin
Ba rats |
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