| 引用本文: |
耿晨曦, 谷冰冰, 孟泳.基于MAPK信号通路探讨中医药治疗肺癌的研究进展[J].湖南中医药大学学报,2026,46(3):651-656[点击复制] |
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| 基于MAPK信号通路探讨中医药治疗肺癌的研究进展 |
| 耿晨曦,谷冰冰,孟泳 |
| (河南中医药大学第二临床医学院, 河南 郑州 450002;河南省中医院肺病科, 河南 郑州 450002) |
| 摘要: |
| 本文系统探讨MAPK信号通路在调控细胞增殖与凋亡、侵袭与转移、免疫应答、逆转耐药及调控细胞周期等方面的作用机制，并综述黄酮类、皂苷类、生物碱类等中药活性成分及益气扶正方、养肺方、肺岩宁颗粒等中药复方通过调控MAPK信号通路抗肺癌的研究进展，旨在为临床抗肺癌药物的研发提供理论依据。 |
| 关键词: 肺癌 MAPK信号通路 中药活性成分 中药复方 分子机制 |
| DOI：10.3969/j.issn.1674-070X.2026.03.030 |
| 投稿时间：2025-10-19 |
| 基金项目:国家科技重大专项（2024ZD0522902）；河南省高等学校重点科研项目计划（24A360011）；河南省中医药科学研究专项课题（2023ZY3008）。 |
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| Research progress in treating lung cancer with TCM based on the MAPK signaling pathway |
| GENG Chenxi, GU Bingbing, MENG Yong |
| (The Second Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou, Henan 450002, China;Department of Pulmonary Diseases, Henan Province Hospital of TCM, Zhengzhou, Henan 450002, China) |
| Abstract: |
| This article systematically explores the mechanism of action of the MAPK signaling pathway in regulating cell proliferation and apoptosis, invasion and metastasis, immunity, reversal of drug resistance, and regulation of the cell cycle. Additionally, it reviews the research progress on anti-lung cancer effects mediated by the modulation of the MAPK signaling pathway through active components of TCM, including flavonoids, saponins, and alkaloids, as well as TCM compound formulas such as Yiqi Fuzheng Formula, Yangfei Formula, and Feiyanning Granules. The aim is to provide a theoretical foundation for the development of clinical anti-lung cancer drugs. |
| Key words: lung cancer MAPK signaling pathway active components of TCM TCM compound formulas molecular mechanism |
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