| 引用本文: |
曾雪芹,陈悦,张湘卓,周俊鹏,白玉豪,吴航宇,李杰,陈伶利.粪菌移植治疗肠道微生态失调所致疾病的研究进展[J].湖南中医药大学学报,2019,39(1):127-131[点击复制] |
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| 粪菌移植治疗肠道微生态失调所致疾病的研究进展 |
| 曾雪芹,陈悦,张湘卓,周俊鹏,白玉豪,吴航宇,李杰,陈伶利 |
| (湖南中医药大学, 湖南 长沙 410208) |
| 摘要: |
| 肠道中数以亿计的微生物构成肠道微生态。肠道微生态在失衡时会引起多种肠道内外疾病。粪菌移植作为一种有效的治疗方法在传统中医中早有应用，近年来重新引起广泛关注。由于该治疗方法可以纠正肠道微生态紊乱，所以在治疗肠道相关疾病中效果最为突出。临床医师和科研人员的不断研究发现，粪便移植不仅能治疗肠道相关疾病，而且在代谢性、心血管、神经性等疾病的治疗上渐露头角。本文从粪菌移植的历史、相关疾病、治疗措施及未来前景等方面结合国内外最新研究进展进行综述，为粪菌移植相关研究和临床应用提供借鉴。 |
| 关键词: 粪菌移植 肠道菌群 肠道微生态失调 |
| DOI：10.3969/j.issn.1674-070X.2019.01.029 |
| 投稿时间：2018-03-23 |
| 基金项目:国家自然科学基金课题（81673963、81874375）；湖南省自然科学基金课题（2018JJ2298）；湖南省科技厅计划项目（2013RS4038）；湖南省教育厅重点项目（16A160）；湖南省中医药科研计划项目（201427）；国家重点学科中医诊断学开放基金项目（2014029）；湖南省中药粉体与创新药物研究省部共建国家重点实验室基地开放基金。 |
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| Research Advances in Fecal Microbiota Transplantation for Diseases Associated with Gut Dysbiosis |
| ZENG Xueqin,CHEN Yue,ZHANG Xiangzhuo,ZHOU Junpeng,BAI Yuhao,WU Hangyu,LI Jie,CHEN Lingli |
| (Hunan University of Traditional Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Intestinal microecology consists of billions of gut microorganisms. Gut dysbiosis is thought to play a key role in the development of a variety of diseases. Fecal microbiota transplantation, as an effective treatment that has long been used in traditional Chinese medicine, has recently attracted widespread attention again. With the effect of correcting gut dysbiosis, it is the most effective treatment of gut-associated diseases. The studies by clinicians and researchers have found that fecal microbiota transplantation can not only treat gut-associated diseases, but also be helpful in the treatment of metabolic, cardiovascular, and neurological diseases. This article reviews the history, related diseases, therapeutic measures, and prospect of fecal microbiota transplantation, as well as the latest research advances in this field, providing a reference for the study and clinical application of fecal microbiota transplantation. |
| Key words: fecal microbiota transplantation intestinal microecology gut dysbiosis |
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