| 引用本文: |
王志琪,张序晴,王尚尧,陈燕盈,彭兰,李赛,曾嵘.基于化学、体内过程和代谢组学的甘草解毒作用研究概况[J].湖南中医药大学学报,2019,39(1):132-137[点击复制] |
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| 基于化学、体内过程和代谢组学的甘草解毒作用研究概况 |
| 王志琪,张序晴,王尚尧,陈燕盈,彭兰,李赛,曾嵘 |
| (湖南中医药大学药学院, 湖南 长沙 410208;湖南中医药大学研究生院, 湖南 长沙 410208) |
| 摘要: |
| 甘草是一味可以解百毒、调和诸药的中药。通过研究甘草对有毒中药/毒性成分及其体内变化过程的影响和甘草对生物体内小分子代谢物的作用来探索其配伍减毒的机制，有助于更好地认识甘草与有毒中药/毒性成分的配伍规律。主要从化学、药动学和代谢组学3个方面介绍了甘草减缓有毒中药/毒性成分的作用及相关机制。 |
| 关键词: 甘草 化学 超分子化学 体内过程 代谢组学 解毒 减毒 |
| DOI：10.3969/j.issn.1674-070X.2019.01.030 |
| 投稿时间：2018-08-21 |
| 基金项目:国家自然科学基金项目（81503492、81473617）；湖南省自然科学基金项目（2015JJ6079）；湖南省教育厅教改项目（湘教通[2016]400-321）；湖南省大学生研究性学习和创新性实验计划项目（湘教通[2018]255-414）。 |
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| An Overview of Licorice Detoxification Research Based on Chemistry, Pharmacokinetics, and Metabolomics |
| WANG Zhiqi,ZHANG Xuqing,WANG Shangyao,CHEN Yanying,PENG Lan,LI Sai,ZENG Rong |
| (School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Graduate School, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Licorice is a Chinese medicine which has the effects of reconciling various medicines and resolving hundreds of toxins. Its mechanism of compatibility and attenuation is explored by studying the effects of licorice on toxic Chinese medicines/components and their changing process in vivo and on small molecule metabolites in vivo, so as to better understand the laws of compatibility of licorice with other toxic Chinese medicines/components. In this paper, the effects of licorice on toxic Chinese medicines/components and related mechanisms are introduced from three aspects:chemistry, pharmacokinetics, and metabolomics. |
| Key words: licorice chemistry supramolecular chemistry process in vivo metabolomics |
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