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任一丹, 陈延, 胡镜清, 谭子虎, 郭珍立.中医药调节免疫炎症治疗癫痫的研究进展[J].湖南中医药大学学报英文版,2026,46(5):1071-1079.[Click to copy
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| 中医药调节免疫炎症治疗癫痫的研究进展 |
| 任一丹,陈延,胡镜清,谭子虎,郭珍立 |
| (湖北中医药大学第一临床学院, 湖北 武汉 430065;湖北省中西医结合医院, 湖北 武汉 430015;天津中医药大学中医学院, 天津 301617;湖北省中医院, 湖北 武汉 430006) |
| 摘要: |
| 癫痫是一种常见的慢性神经系统疾病，其发病机制尚未完全明确，但免疫炎症反应贯穿癫痫发生发展的全过程。本文系统阐述了中医药通过调节免疫炎症治疗癫痫的分子机制与临床疗效，总结中药单体、活性成分及复方通过调控胶质细胞极化、NOD样受体蛋白3（NLRP3）炎症小体激活、促炎性细胞因子释放、免疫微环境稳态及核因子κB（NF-κB）、γ-氨基丁酸（GABA）能传递、高迁移率族蛋白B1（HMGB1）等信号通路多靶点、多途径缓解癫痫发作的实验与临床证据，以期为癫痫的临床研究和药物研发提供参考。 |
| 关键词: 癫痫|中医药|免疫炎症|炎症因子|神经胶质细胞|免疫微环境 |
| DOI：10.3969/j.issn.1674-070X.2026.05.029 |
| Received:January 20, 2026 |
| 基金项目:湖北省中西医结合医院“中西医结合未来医学范式启航工程”培育项目（QH202510）。 |
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| Research progress on Chinese medicine regulating immune inflammation in treating epilepsy |
| REN Yidan, CHEN Yan, HU Jingqing, TAN Zihu, GUO Zhenli |
| (The First Clinical Medical College, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, China;Hubei Provincial Hospital of Integrated Chinese and Western Medicine, Wuhan, Hubei 430015, China;Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, Hubei 430006, China) |
| Abstract: |
| Epilepsy is a common chronic neurological disorder with incompletely clarified pathogenesis. However, immune-inflammatory responses are involved throughout the entire process of the onset and progression of epilepsy. This paper systematically elucidates the molecular mechanisms and clinical efficacy of Chinese medicine in regulating immune inflammation for the treatment of epilepsy. It summarizes experimental and clinical evidence demonstrating that TCM monomers, active constituents, and formulas alleviate epileptic seizures through multi-target and multi-pathway mechanisms, including regulation of glial cell activation, NOD-like receptor protein 3 (NLRP3) inflammasome activation, pro-inflammatory cytokine release, immune microenvironment homeostasis, and signaling pathways such as nuclear factor κB (NF-κB), γ-aminobutyric acid (GABA)ergic transmission, and high mobility group box 1 (HMGB1). It aims to provide a reference for clinical research and drug development for epilepsy. |
| Key words: epilepsy|Chinese medicine|immune inflammation|inflammatory factor|neuroglial cell|immune microenvironment |
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