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刘方宇, 康婕, 隋楠.溃疡性结肠炎(寒热错杂证)炎癌转化的中医药防治[J].湖南中医药大学学报英文版,2025,45(9):1794-1800.[Click to copy
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| 溃疡性结肠炎(寒热错杂证)炎癌转化的中医药防治 |
| 刘方宇,康婕,隋楠 |
| (辽宁中医药大学, 辽宁 沈阳 110847;辽宁中医药大学附属第三医院, 辽宁 沈阳 110003) |
| 摘要: |
| 溃疡性结肠炎（UC）是一种以直肠和结肠黏膜慢性炎症为特征的疾病，临床主要症状为腹痛、黏液脓血便及里急后重等。UC病程迁延反复，与结直肠癌（CRC）发生密切相关。中医学认为寒热错杂贯穿UC炎癌转化的过程始终，而中医药在调控UC炎癌转化中展现出独特优势。本文从中医寒热辨证的角度系统阐释UC“炎症-异型增生-癌变”进程中寒热错杂的病理特征及病机演变，结合现代医学分子机制研究，探讨经典方剂（如乌梅丸、半夏泻心汤和左金丸）及单味中药（如马齿苋、虎杖、苦参和姜黄）通过多靶点干预炎症微环境、调节肠道菌群及免疫稳态的作用，旨在为中西医结合防治UC炎癌转化提供理论依据和新思路。 |
| 关键词: 溃疡性结肠炎 炎癌转化 结直肠癌 寒热错杂 炎症微环境 肠道菌群 免疫稳态 |
| DOI：10.3969/j.issn.1674-070X.2025.09.030 |
| Received:April 08, 2025 |
| 基金项目:国家自然科学基金项目(82174370); 国家中医药管理局青年岐黄学者项目(2022256)。 |
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| Prevention and treatment of inflammation-cancer transformation in ulcerative colitis （combined cold and heat pattern） with Chinese medicine |
| LIU Fangyu, KANG Jie, SUI Nan |
| (Liaoning University of Traditional Chinese Medicine, Liaoning, Shenyang 110847, China;The Third Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Liaoning, Shenyang 110003, China) |
| Abstract: |
| Ulcerative colitis（UC） is a chronic disease characterized by the inflammation of the rectal and colonic mucosa,with main clinical symptoms including abdominal pain, mucopurulent bloody stool, and tenesmus. It follows a prolonged and recurrent disease course and is closely related to the occurrence of colorectal cancer（CRC）. Chinese medicine（CM） posits that the combined cold and heat persists throughout the entire process of inflammation-cancer transformation in UC, and CM has demonstrated unique advantages in regulating this progression. This paper systematically elucidates the pathological features and pathogenesis evolution of the combined cold and heat in the process of "inflammation-dysplasia-canceration" in UC from the CM perspective of cold-heat pattern differentiation. Integrating evidence from modern medical molecular mechanism research, this paper explores the multi-target effects of classical formulas such as Wumei Pill, Banxia Xiexin Decoction, and Zuojin Pill, and several single Chinese medicines including Machixian（Portulacae Herba）, Huzhang（Polygoni Cuspidati Rhizoma et Radix）, Kushen（Sophorae Flavescentis Radix）, and Jianghuang（Curcumae Longae Rhizoma） in modulating the inflammatory microenvironment, regulating gut microbiota,and restoring immune homeostasis in UC. It aims to provide theoretical support and new approaches for the prevention and treatment of inflammation-cancer transformation in UC with integrated Chinese and Western medicine. |
| Key words: ulcerative colitis inflammation-cancer transformation colorectal cancer combined cold and heat inflammatory microenvironment gut microbiota immune homeostasis |
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