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张博玲, 卢爱宵, 杨熙文, 叶俊辰, 张丽娜, 郭洪波.基于“调中复衡”理论论治化疗所致周围神经病变[J].湖南中医药大学学报英文版,2025,45(9):1710-1715.[Click to copy
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| 基于“调中复衡”理论论治化疗所致周围神经病变 |
| 张博玲,卢爱宵,杨熙文,叶俊辰,张丽娜,郭洪波 |
| (山西中医药大学, 山西 晋中 030619;山西医科大学第一医院, 山西 太原 030001) |
| 摘要: |
| 近年来，化疗所致周围神经病变（CIPN）发生率逐渐升高,但目前西医尚无有效的药物治疗。CIPN以脾肾亏虚本，瘀阻络脉为标，正虚与邪实相互影响致瘀贯穿全程。本文阐释八纲辨证与CIPN气血不调、虚实不调、阴阳不调、脏腑不调之病机演变，脾肾亏虚是CIPN之本，瘀阻脉络是其主要病理环节。治疗上应以散瘀复衡为核心，调中焦以复升降、散瘀浊以通络脉，以期为临床论治CIPN提供新思路。 |
| 关键词: 化疗所致周围神经病变 调中复衡 散瘀通络 扶正固本 调节脏腑 平衡阴阳 八纲辨证 |
| DOI：10.3969/j.issn.1674-070X.2025.09.017 |
| Received:May 05, 2025 |
| 基金项目:山西省中医药管理局科研课题(2022ZYYC073)。 |
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| Treatment of chemotherapy-induced peripheral neuropathy based on the theory of “regulating the middle jiao to restore balance” |
| ZHANG Boling, LU Aixiao, YANG Xiwen, YE Junchen, ZHANG Li'na, GUO Hongbo |
| (Shanxi University of Chinese Medicine, Jinzhong, Shanxi 030619, China;The First Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China) |
| Abstract: |
| Chemotherapy-induced peripheral neuropathy（CIPN） is a growing concern in modern medicine, with limited effective pharmacological interventions currently available. CIPN is fundamentally characterized by deficiency of the spleen and kidney, with collateral vessel obstruction serving as its secondary manifestation. Deficiency of healthy qi and excess of pathogenic factors interact throughout the disease course, leading to persistent blood stasis. This article elucidates the pathological evolution of CIPN through the lens of Eight-Principle Pattern Differentiation, highlighting imbalances in qi and blood, deficiency and excess, yin and yang, as well as visceral dysfunction. Deficiency of the spleen and kidney constitutes the root cause of CIPN, while blood stasis obstructing the collaterals represents its core pathological mechanism. In treatment, the core principle should be to dissipate blood stasis and restore balance, regulating the middle jiao to normalize ascending and descending functions, and dissipating blood stasis and turbidity to unblock the collaterals. This paper aims to provide a new perspective for the clinical management of CIPN. |
| Key words: chemotherapy-induced peripheral neuropathy regulating the middle jiao and restoring balance dissipating blood stasis to unblock collaterals reinforcing healthy qi to strengthen the body regulating the zang-fu organs balancing yin and yang pattern differentiation by the eight principles |
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