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刘桂成, 田赛男, 逯晶, 彭清华, 胡淑娟.基于免疫耐受从“卫气内伐”论治自身免疫性葡萄膜炎[J].湖南中医药大学学报英文版,2025,45(9):1698-1703.[Click to copy
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| 基于免疫耐受从“卫气内伐”论治自身免疫性葡萄膜炎 |
| 刘桂成,田赛男,逯晶,彭清华,胡淑娟 |
| (湖南中医药大学, 湖南 长沙 410208;湖南中医药大学第一附属医院, 湖南 长沙 410007) |
| 摘要: |
| 基于中医学对免疫性疾病的认识，并结合免疫耐受与卫气的类比认识，提出以“卫气内伐”理论指导辨治自身免疫性葡萄膜炎（AU）。“卫气内伐”指机体负责防御的卫气失道、失职、失辨，留滞内伐，戕及本体。AU患者营卫不和，卫气内伐自戕，伴随病程进展，留滞的卫气与病理产物胶结成邪，使本病缠绵难愈。AU的治疗当注重和营卫以复耐受，消邪壅而疏卫滞，清郁卫以防异变。本文从机制-理论-治法逻辑线阐述“卫气内伐”理论下的AU发病机制与治疗思路，为中医辨证与现代免疫理论对接、协同治疗AU提供借鉴。 |
| 关键词: 自身免疫性葡萄膜炎 卫气 免疫耐受 卫气内伐 调和营卫 |
| DOI：10.3969/j.issn.1674-070X.2025.09.015 |
| Received:July 24, 2025 |
| 基金项目:国家自然科学基金项目(82104936); 湖南省卫生健康委员会高层次人才重大科研专项(20230530); 湖南省教育厅科学研究项目一般项目(22C0191); 湖南中医药大学研究生创新课题(2024CX155)。 |
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| Treatment of autoimmune uveitis from the perspective of “internal attack by Wei-defensive qi” based on immune tolerance |
| LIU Guicheng, TIAN Sainan, LU Jing, PENG Qinghua, HU Shujuan |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China) |
| Abstract: |
| Based on the understanding of immune diseases in Chinese medicine（CM）, and combined with the analogical understanding of immune tolerance and Wei-defensive qi, this paper proposes guiding the pattern differentiation and treatment of autoimmune uveitis（AU） with the theory of "internal attack by Wei-defensive qi." "Internal attack by Wei-defensive qi" refers to a state where the body’s Wei-defensive qi, responsible for protection, deviates from its normal path, fails to perform its duties, and loses its ability to discriminate, resulting in its stagnation and subsequent internal attack that harms the body itself. In AU patients,there is disharmony between Ying-nutrient qi and Wei-defensive qi, with the Wei-defensive qi attacking and damaging the body on its own. As the disease progresses, the stagnant Wei-defensive qi combines with pathological products to form pathogenic factors,making the disease persistent and difficult to cure. The treatment of AU should focus on harmonizing Ying-nutrients and Weidefense to restore tolerance, eliminating pathogenic blockages to dredge stagnant Wei-defensive qi, and clearing stagnant Weidefensive qi to prevent abnormal changes. This paper elaborates on the pathogenesis and treatment approach of AU under the theory of "internal attack by Wei-defensive qi" from a logical sequence of mechanism-theory-treatment, providing a reference for integrating CM pattern differentiation with modern immune theory for the collaborative treatment of AU. |
| Key words: autoimmune uveitis Wei-defensive qi immune tolerance internal attack by Wei-defensive qi harmonizing Ying-nutrients and Wei-defense |
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