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刘光诺, 王振刚, 蓝锦绣, 梁翠, 刘诗娟.基于“气火失衡”理论探讨甲状腺结节“结癌转化”防治[J].湖南中医药大学学报英文版,2025,45(8):1512-1517.[Click to copy
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| 基于“气火失衡”理论探讨甲状腺结节“结癌转化”防治 |
| 刘光诺,王振刚,蓝锦绣,梁翠,刘诗娟 |
| (广西中医药大学研究生院, 广西 南宁 530000;广西中医药大学第一附属医院, 广西 南宁 530000) |
| 摘要: |
| 甲状腺结节为常见内分泌疾病，多数患者因未及时发现或未予重视，病情迁延日久，部分转变为癌。“结癌转化”是一个动态变化的过程，本文基于中医学“气火失衡”理论，系统阐释甲状腺结节“结癌转化”的病理机制与防治策略。脾胃虚弱是导致元气亏虚与阴火亢盛动态失衡的核心环节，由此引发的“虚、郁、痰、火、毒”病理链驱动结节微环境重塑。具体表现为脾胃运化失司致痰瘀互结，阴火煎灼促痰瘀毒化，最终形成“毒损脉络”的癌变病理基础。遵循治未病理念，提出三级防治策略：早期健脾益气、固本培元，中期调气降火、分消痰瘀，后期解毒扶正、化瘀通络，以期为防治甲状腺结节恶性转化提供中医理论指导与临床实践路径，彰显中医药在改善症状、调控微环境及逆转病理进程中的独特优势。 |
| 关键词: 甲状腺结节 气火失衡 癌变 防治 结癌转化 治未病 |
| DOI：10.3969/j.issn.1674-070X.2025.08.017 |
| Received:June 16, 2025 |
| 基金项目:广西自然科学基金项目(2024GXNSFAA010285,2025GXNSFAA069339);广西中医药适宜技术开发与推广项目合同书(GZSY23-23) |
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| Prevention and treatment of "malignant transformation" of thyroid nodules based on the theory of "qi-fire imbalance" |
| LIU Guangnuo, WANG Zhengang, LAN Jinxiu, LIANG Cui, LIU Shijuan |
| (Graduate School of Guangxi University of Chinese Medicine, Nanning, Guangxi 530000, China;The First Hospital of Guangxi University of Chinese Medicine, Nanning, Guangxi 530000, China) |
| Abstract: |
| Thyroid nodule is a common endocrine disease. Due to delayed detection or insufficient attention, many patients experience prolonged disease progression, with some nodules eventually transforming into cancer. The process of "malignant transformation of thyroid nodules" is dynamic. Based on the Chinese medicine（CM） theory of "qi-fire imbalance", this paper systematically elucidated the pathological mechanisms and prevention and treatment strategies for the transformation of thyroid nodules into cancer. Spleen-stomach weakness is the central link leading to the dynamic imbalance between yuan-primordial qi deficiency and excessive yin fire, which initiates a pathological cascade of "deficiency, stagnation, phlegm, fire, and toxin",thereby remodeling the nodule microenvironment. Specifically, the dysfunction of spleen and stomach transportation and transformation results in intertwined phlegm and blood stasis, while excessive yin fire promotes the transformation of phlegm and stasis into toxins, ultimately forming the pathological basis for cancer through "toxin damaging the collaterals". Following the principle of preventing a disease before it arises, a three-stage strategy was proposed: in the early stage, strengthening the spleen and benefiting qi to strengthen the body and nourish the origin; in the middle stage, regulating qi and reducing fire to resolve phlegm and stasis; and in the late stage, detoxifying and supporting the healthy qi to transform stasis and unblock collaterals. This approach aims to provide a theoretical and practical CM pathway for preventing malignant transformation of thyroid nodules, highlighting the unique advantages of CM in alleviating symptom, regulating microenvironment, and reversing pathological progression. |
| Key words: thyroid nodules qi-fire imbalance malignant transformation prevention and treatment malignant transformation of thyroid nodules preventing a disease before it arises |
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