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段春霞, 戚予晶, 牛姝, 王文静.穴位埋线联合温针灸治疗肥胖合并代谢综合征患者的临床研究[J].湖南中医药大学学报英文版,2025,45(8):1482-1489.[Click to copy
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| 穴位埋线联合温针灸治疗肥胖合并代谢综合征患者的临床研究 |
| 段春霞,戚予晶,牛姝,王文静 |
| (石家庄市人民医院, 河北 石家庄 050000) |
| 摘要: |
| 目的 探讨穴位埋线联合温针灸对肥胖合并代谢综合征患者的临床疗效。方法 将2021年5月至2024年5月在石家庄市人民医院就诊的108例肥胖合并代谢综合征患者随机分为对照组、研究组，各54例。对照组51例患者（脱落3例）给予常规基础治疗，研究组50例患者（脱落4例）在常规基础治疗前提下给予穴位埋线联合温针灸治疗。治疗12周后（T1），对比两组临床疗效；治疗前（T0）、T1、治疗结束后6个月（T2），比较两组的人体测量学指标[腰围（WC）、腰臀比（WHR）、体质量指数（BMI）]、糖代谢和胰岛功能指标[糖化血红蛋白（HbA1c）、餐后2 h血糖（2hPG）、空腹血糖（FBG）、胰岛β细胞功能指数（HOMA-β）、胰岛素抵抗指数（HOMA-IR）]、脂代谢指标[总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）];T1、T0时，比较两组的血压[舒张压（DBP）、收缩压（SBP）]和血清炎症指标[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]。结果 T1时，研究组总有效率大于对照组（P<0.05）。T1、T2时，两组BMI、WC和WHR较T0时降低（P<0.05），且研究组均低于对照组（P<0.05）。T1、T2时，两组FBG、2hPG、HbA1c和HOMA-IR较T0时降低（P<0.05），且研究组均低于对照组（P<0.05）；两组HOMA-β较T0时升高（P<0.05），且研究组高于对照组（P<0.05）。T1、T2时，两组TC、TG、LDL-C较T0时降低（P<0.05），且研究组均低于对照组（P<0.05）；两组HDL-C较T0时升高（P<0.05），且研究组高于对照组（P<0.05）。T1时，两组DBP、SBP、IL-6和TNF-α较T0降低（P<0.05），且研究组均低于对照组（P<0.05）。两组治疗期间不良事件发生率比较，差异无统计学意义（P>0.05）。结论 穴位埋线联合温针灸治疗肥胖合并代谢综合征患者疗效显著，能够发挥降脂减肥和降压的作用，改善机体胰岛素抵抗和代谢紊乱，抑制炎症反应，值得临床推广应用。 |
| 关键词: 肥胖 代谢综合征 穴位埋线 温针灸 降脂减肥 糖代谢 脂代谢 胰岛功能 |
| DOI：10.3969/j.issn.1674-070X.2025.08.012 |
| Received:November 19, 2024 |
| 基金项目:河北省医学科学研究课题计划项目(20241867) |
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| Clinical study on catgut-embedding therapy combined with needle-warming moxibustion in treating obese patients with metabolic syndrome |
| DUAN Chunxia, QI Yujing, NIU Shu, WANG Wenjing |
| (Shijiazhuang People's Hospital, Shijiazhuang, Hebei 050000, China) |
| Abstract: |
| Objective To explore the clinical efficacy of catgut-embedding therapy combined with needle-warming moxibustion on obese patients with metabolic syndrome. Methods A total of 108 obese patients with metabolic syndrome treated in Shijiazhuang People’s Hospital from May 2021 to May 2024 were randomly divided into control group and study group, with 54patients in each group. The control group（51 patients completed the study, 3 dropouts） received conventional basic treatment, while the study group（50 patients completed the study, 4 dropouts） received catgut-embedding therapy combined with needle-warming moxibustion in addition to conventional treatment. After 12 weeks of treatment（T1）, clinical efficacy was compared between the two groups. Anthropometric indicators [waist circumference（WC）, waist-to-hip ratio（WHR）, body mass index（BMI）], glycometabolism and islet function indices [glycated hemoglobin（HbA1c）, 2-hour postprandial blood glucose（2hPG）, fasting blood glucose（FBG）,homeostatic model assessment of β-cell function（HOMA-β）, and insulin resistance index（HOMA-IR）], and lipid metabolism indicators [total cholesterol（TC）, high-density lipoprotein cholesterol（HDL-C）, triglycerides（TG）, low-density lipoprotein cholesterol（LDL-C）] were measured at baseline（T0）, T1, and six months post-treatment（T2）. Blood pressure [diastolic blood pressure（DBP）,systolic blood pressure（SBP）] and serum inflammatory markers [interleukin-6（IL-6）, tumor necrosis factor-α（TNF-α）] were compared at T0 and T1. Results At T1, the total effective rate in the study group was significantly higher than that in the control group（P＜0.05）.At T1 and T2, BMI, WC, and WHR decreased in both groups compared to T0（P＜0.05）, with lower values in the study group than the control group（P＜0.05）. At T1 and T2, FBG, 2hPG, HbA1c, and HOMA-IR in both groups decreased compared to T0（P＜0.05）,with lower levels in the study group（P＜0.05）. HOMA-β increased in both groups compared to T0（P＜0.05）, with higher values in the study group（P＜0.05）. At T1 and T2, TC, TG, and LDL-C decreased in both groups compared to T0（P＜0.05）, with lower levels in the study group（P＜0.05）, while HDL-C increased compared to T0（P＜0.05）, with higher levels in the study group（P＜0.05）. At T1, DBP,SBP, IL-6, and TNF-α decreased in both groups compared to T0（P＜0.05）, with lower levels in the study group（P＜0.05）. There was no statistically significant difference in the incidence of adverse events between the two groups during treatment（P＞0.05）. Conclusion Catgut-embedding therapy combined with needle-warming moxibustion demonstrates significant efficacy on obese patients with metabolic syndrome. It can exert lipid-lowering and anti-obesity effects, lower blood pressure, improve insulin resistance and metabolic disorders, and inhibit inflammatory responses, making it worthy of clinical promotion. |
| Key words: obesity metabolic syndrome catgut-embedding therapy needle-warming moxibustion lipid-lowering and anti-obesity glycometabolism lipid metabolism islet function |
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